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Pigc phosphatidylinositol glycan anchor biosynthesis, class C [ Mus musculus (house mouse) ]

Gene ID: 67292, updated on 5-Mar-2024

Summary

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Official Symbol
Pigcprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Cprovided by MGI
Primary source
MGI:MGI:1914542
See related
Ensembl:ENSMUSG00000026698 AllianceGenome:MGI:1914542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3110030E07Rik
Summary
Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in eye; facial bone primordium; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PIGC (phosphatidylinositol glycan anchor biosynthesis class C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 10.1), limb E14.5 (RPKM 9.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H2.1; 1 69.95 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161796757..161801029)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161969188..161973460)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10050 Neighboring gene cyclin-dependent kinase 7 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2578 Neighboring gene SUN domain containing ossification factor Neighboring gene STARR-positive B cell enhancer ABC_E7766 Neighboring gene STARR-seq mESC enhancer starr_02830 Neighboring gene RIKEN cDNA 4930558K02 gene Neighboring gene predicted gene, 31925 Neighboring gene STARR-positive B cell enhancer ABC_E4367 Neighboring gene STARR-positive B cell enhancer mm9_chr1:163906574-163906875 Neighboring gene STARR-seq mESC enhancer starr_02833 Neighboring gene RIKEN cDNA 2810442N19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163930050-163930233 Neighboring gene dynamin 3 Neighboring gene STARR-seq mESC enhancer starr_02834 Neighboring gene VISTA enhancer mm712 Neighboring gene STARR-seq mESC enhancer starr_02835 Neighboring gene STARR-seq mESC enhancer starr_02836 Neighboring gene microRNA 199a-2 Neighboring gene dynamin 3, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit C
Names
PIG-C
phosphatidylinositol-glycan biosynthesis class C protein
NP_001034134.1
NP_080354.1
XP_006497022.1
XP_030098184.1
XP_036009010.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039045.1 → NP_001034134.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

    See identical proteins and their annotated locations for NP_001034134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK152660, CAAA01056494, CJ171161
    Consensus CDS
    CCDS15419.1
    UniProtKB/Swiss-Prot
    Q3U7H3, Q9CXR4
    UniProtKB/TrEMBL
    Q3TDK1, Q3U1G9
    Related
    ENSMUSP00000107221.3, ENSMUST00000111594.3
    Conserved Domains (1) summary
    pfam06432
    Location:14 → 284
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

  2. NM_026078.2 → NP_080354.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

    See identical proteins and their annotated locations for NP_080354.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK014096, CAAA01056494, CJ171161
    Consensus CDS
    CCDS15419.1
    UniProtKB/Swiss-Prot
    Q3U7H3, Q9CXR4
    UniProtKB/TrEMBL
    Q3TDK1, Q3U1G9
    Related
    ENSMUSP00000028021.7, ENSMUST00000028021.7
    Conserved Domains (1) summary
    pfam06432
    Location:14 → 284
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    161796757..161801029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496959.3 → XP_006497022.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

    See identical proteins and their annotated locations for XP_006497022.1

    UniProtKB/Swiss-Prot
    Q3U7H3, Q9CXR4
    UniProtKB/TrEMBL
    Q3TDK1, Q3U1G9
    Conserved Domains (1) summary
    pfam06432
    Location:14 → 284
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

  2. XM_030242324.2 → XP_030098184.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

    UniProtKB/Swiss-Prot
    Q3U7H3, Q9CXR4
    UniProtKB/TrEMBL
    Q3TDK1, Q3U1G9
    Conserved Domains (1) summary
    pfam06432
    Location:14 → 284
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

  3. XM_036153117.1 → XP_036009010.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

    UniProtKB/Swiss-Prot
    Q3U7H3, Q9CXR4
    UniProtKB/TrEMBL
    Q3TDK1, Q3U1G9
    Related
    ENSMUSP00000141646.2, ENSMUST00000193784.2
    Conserved Domains (1) summary
    pfam06432
    Location:14 → 284
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXR4.1 GenPept UniProtKB/Swiss-Prot:Q9CXR4

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