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Stk35 serine/threonine kinase 35 [ Mus musculus (house mouse) ]

Gene ID: 67333, updated on 11-Apr-2024

Summary

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Official Symbol
Stk35provided by MGI
Official Full Name
serine/threonine kinase 35provided by MGI
Primary source
MGI:MGI:1914583
See related
Ensembl:ENSMUSG00000037885 AllianceGenome:MGI:1914583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLIK1; Stk35l1; 1700054C12Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle. Predicted to act upstream of or within phosphorylation. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in bone; cerebellum; pelvic girdle skeleton; and sensory organ. Orthologous to human STK35 (serine/threonine kinase 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 34.5), ovary adult (RPKM 13.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stk35 in Genome Data Viewer
Location:
2 F1; 2 63.19 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129642437..129674207)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129800517..129832287)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05677 Neighboring gene prodynorphin Neighboring gene STARR-seq mESC enhancer starr_05678 Neighboring gene STARR-seq mESC enhancer starr_05679 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1 Neighboring gene STARR-seq mESC enhancer starr_05680 Neighboring gene STARR-seq mESC enhancer starr_05681 Neighboring gene STARR-seq mESC enhancer starr_05682 Neighboring gene serine/threonine kinase 35, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_05684 Neighboring gene predicted gene, 39933 Neighboring gene STARR-seq mESC enhancer starr_05686 Neighboring gene transglutaminase 3, E polypeptide Neighboring gene predicted gene, 52561

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuclear retention of importin α coordinates cell fate through changes in gene expression. Yasuda Y, et al. EMBO J, 2012 Jan 4. PMID 21964068, Free PMC Article
  2. The STK35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress. Miyamoto Y, et al. Biol Open, 2018 Aug 6. PMID 29970477, Free PMC Article
  3. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. Goyal P, et al. PLoS One, 2009 Sep 16. PMID 19756140, Free PMC Article
  4. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation by eIF2 alpha phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 35
Names
CLP-36 interacting kinase
serine/threonine-protein kinase 35 L1
NP_001033724.2
NP_899085.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038635.2 → NP_001033724.2  serine/threonine-protein kinase 35 isoform b

    Status: VALIDATED

    Source sequence(s)
    AI431080, AK085193, AL808137
    Consensus CDS
    CCDS16731.2
    UniProtKB/TrEMBL
    E9PXA2
    Related
    ENSMUSP00000132862.3, ENSMUST00000166282.3
    Conserved Domains (1) summary
    cl21453
    Location:206 → 304
    PKc_like; Protein Kinases, catalytic domain

  2. NM_183262.3 → NP_899085.3  serine/threonine-protein kinase 35 isoform a

    See identical proteins and their annotated locations for NP_899085.3

    Status: VALIDATED

    Source sequence(s)
    AI431080, AK006778, AK085193, AL808137, BC047277
    Consensus CDS
    CCDS16732.2
    UniProtKB/Swiss-Prot
    A2ANF2, Q3TMD8, Q80ZW0, Q8BIC2
    Related
    ENSMUSP00000126541.3, ENSMUST00000165413.9
    Conserved Domains (2) summary
    smart00220
    Location:207 → 528
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13977
    Location:206 → 534
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    129642437..129674207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZW0.3 GenPept UniProtKB/Swiss-Prot:Q80ZW0

Gene LinkOut

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