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Tmco5 transmembrane and coiled-coil domains 5 [ Mus musculus (house mouse) ]

Gene ID: 67356, updated on 5-Mar-2024

Summary

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Official Symbol
Tmco5provided by MGI
Official Full Name
transmembrane and coiled-coil domains 5provided by MGI
Primary source
MGI:MGI:1914606
See related
Ensembl:ENSMUSG00000027355 AllianceGenome:MGI:1914606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmco5a; 1700095F04Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in spinal cord and testis. Orthologous to human TMCO5A (transmembrane and coiled-coil domains 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 31.5) See more
Orthologs
human all
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Genomic context

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See Tmco5 in Genome Data Viewer
Location:
2 E5; 2 59.03 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (116709174..116722987)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (116878693..116892506)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAB5B, member RAS oncogene family pseudogene Neighboring gene STARR-seq mESC enhancer starr_05435 Neighboring gene predicted gene 13990 Neighboring gene RIKEN cDNA D330050G23 gene Neighboring gene predicted gene, 46758 Neighboring gene STARR-seq mESC enhancer starr_05436 Neighboring gene predicted gene, 25514

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse TMCO5 is localized to the manchette microtubules involved in vesicle transfer in the elongating spermatids. Yamase K, et al. PLoS One, 2019. PMID 31393949, Free PMC Article
  2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tmco5 may have a role in vesicle transport along the manchette.
    Title: Mouse TMCO5 is localized to the manchette microtubules involved in vesicle transfer in the elongating spermatids.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane and coiled-coil domain-containing protein 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355572.2 → NP_001342501.1  transmembrane and coiled-coil domain-containing protein 5A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL845318
    UniProtKB/TrEMBL
    Z4YLS6
    Conserved Domains (1) summary
    pfam14992
    Location:30 → 282
    TMCO5; TMCO5 family

  2. NM_001379337.1 → NP_001366266.1  transmembrane and coiled-coil domain-containing protein 5A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes the longer isoform (1).
    Source sequence(s)
    AL845318
    UniProtKB/Swiss-Prot
    A2ARB1, Q9CVN5, Q9D9D5
    UniProtKB/TrEMBL
    Z4YLS6
    Conserved Domains (1) summary
    pfam14992
    Location:28 → 302
    TMCO5; TMCO5 family

  3. NM_026104.5 → NP_080380.1  transmembrane and coiled-coil domain-containing protein 5A isoform 1

    See identical proteins and their annotated locations for NP_080380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL845318
    Consensus CDS
    CCDS16569.1
    UniProtKB/Swiss-Prot
    A2ARB1, Q9CVN5, Q9D9D5
    UniProtKB/TrEMBL
    Z4YLS6
    Related
    ENSMUSP00000028834.3, ENSMUST00000028834.3
    Conserved Domains (1) summary
    pfam14992
    Location:28 → 302
    TMCO5; TMCO5 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    116709174..116722987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239746.3 → XP_011238048.1  transmembrane and coiled-coil domain-containing protein 5A isoform X1

    Conserved Domains (1) summary
    pfam14992
    Location:83 → 355
    TMCO5; TMCO5 family

  2. XM_011239747.3 → XP_011238049.1  transmembrane and coiled-coil domain-containing protein 5A isoform X2

    Conserved Domains (1) summary
    pfam14992
    Location:83 → 345
    TMCO5; TMCO5 family

  3. XM_011239748.3 → XP_011238050.1  transmembrane and coiled-coil domain-containing protein 5A isoform X3

    Conserved Domains (1) summary
    pfam14992
    Location:83 → 335
    TMCO5; TMCO5 family

  4. XM_011239749.3 → XP_011238051.1  transmembrane and coiled-coil domain-containing protein 5A isoform X4

    Conserved Domains (1) summary
    pfam14992
    Location:83 → 216
    TMCO5; TMCO5 family

RNA

  1. XR_004940710.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9D5.1 GenPept UniProtKB/Swiss-Prot:Q9D9D5

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