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Mtpap mitochondrial poly(A) polymerase [ Mus musculus (house mouse) ]

Gene ID: 67440, updated on 11-Apr-2024

Summary

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Official Symbol
Mtpapprovided by MGI
Official Full Name
mitochondrial poly(A) polymeraseprovided by MGI
Primary source
MGI:MGI:1914690
See related
Ensembl:ENSMUSG00000024234 AllianceGenome:MGI:1914690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Papd1; Tent6; 0610027A18Rik
Summary
Predicted to enable several functions, including metal ion binding activity; protein homodimerization activity; and ribonucleotide binding activity. Predicted to be involved in histone mRNA catabolic process and mRNA polyadenylation. Predicted to act upstream of or within mRNA processing. Located in mitochondrion. Is expressed in several structures, including early conceptus; liver lobe; and oocyte. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.5), whole brain E14.5 (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A1; 18 2.77 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4375573..4399888)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4375589..4399888)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 8 Neighboring gene RIKEN cDNA 4833419F23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:4375540-4375727 Neighboring gene STARR-seq mESC enhancer starr_43677 Neighboring gene STARR-seq mESC enhancer starr_43679 Neighboring gene predicted gene, 52359 Neighboring gene protein arginine N-methyltransferase 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
  2. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables UTP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial RNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
poly(A) RNA polymerase, mitochondrial
Names
PAP associated domain containing 1
PAP-associated domain-containing protein 1
polynucleotide adenylyltransferase
NP_001347937.1
NP_001347938.1
NP_080433.1
XP_006526247.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361008.2 → NP_001347937.1  poly(A) RNA polymerase, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC138768, AEKQ02123947
    UniProtKB/TrEMBL
    A0A3Q4L2Q3
    Conserved Domains (2) summary
    cd05402
    Location:28 → 99
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:57 → 248
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  2. NM_001361009.2 → NP_001347938.1  poly(A) RNA polymerase, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC138768, AEKQ02123947
    UniProtKB/TrEMBL
    A0A3Q4L2Q3
    Conserved Domains (2) summary
    cd05402
    Location:28 → 99
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:57 → 248
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  3. NM_026157.4 → NP_080433.1  poly(A) RNA polymerase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_080433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC138768, AEKQ02123947
    Consensus CDS
    CCDS37718.1
    UniProtKB/Swiss-Prot
    Q3UXJ1, Q8C651, Q9D0D3
    Related
    ENSMUSP00000025077.7, ENSMUST00000025077.7
    Conserved Domains (2) summary
    cd05402
    Location:209 → 347
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:441 → 486
    PAP_assoc; Cid1 family poly A polymerase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    4375573..4399888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526184.5 → XP_006526247.1  poly(A) RNA polymerase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006526247.1

    UniProtKB/TrEMBL
    A0A3Q4L2Q3
    Conserved Domains (2) summary
    cd05402
    Location:28 → 99
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:57 → 248
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

RNA

  1. XR_004939877.1 RNA Sequence

  2. XR_004939879.1 RNA Sequence

  3. XR_004939881.1 RNA Sequence

  4. XR_004939882.1 RNA Sequence

  5. XR_004939880.1 RNA Sequence

  6. XR_004939878.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0D3.1 GenPept UniProtKB/Swiss-Prot:Q9D0D3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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