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Mtpap mitochondrial poly(A) polymerase [ Mus musculus (house mouse) ]

Gene ID: 67440, updated on 23-Jun-2021

Summary

Official Symbol
Mtpapprovided by MGI
Official Full Name
mitochondrial poly(A) polymeraseprovided by MGI
Primary source
MGI:MGI:1914690
See related
Ensembl:ENSMUSG00000024234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pa; Tent; Papd1; Tent6; AW551379; 0610027A18Rik
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.5), whole brain E14.5 (RPKM 4.3) and 28 other tissues See more
Orthologs
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Genomic context

See Mtpap in Genome Data Viewer
Location:
18; 18 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4375573..4399888)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4375589..4399888)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (4375590..4397328)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 8 Neighboring gene RIKEN cDNA 4833419F23 gene Neighboring gene predicted gene, 52359 Neighboring gene protein arginine N-methyltransferase 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables UTP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polynucleotide adenylyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA polyadenylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
poly(A) RNA polymerase, mitochondrial
Names
PAP associated domain containing 1
PAP-associated domain-containing protein 1
polynucleotide adenylyltransferase
NP_001347937.1
NP_001347938.1
NP_080433.1
XP_006526247.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361008.2NP_001347937.1  poly(A) RNA polymerase, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC138768, AEKQ02123947
    Conserved Domains (2) summary
    cd05402
    Location:2899
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:57248
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  2. NM_001361009.2NP_001347938.1  poly(A) RNA polymerase, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC138768, AEKQ02123947
    Conserved Domains (2) summary
    cd05402
    Location:2899
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:57248
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  3. NM_026157.4NP_080433.1  poly(A) RNA polymerase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_080433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC138768, AEKQ02123947
    Consensus CDS
    CCDS37718.1
    UniProtKB/Swiss-Prot
    Q9D0D3
    Related
    ENSMUSP00000025077.7, ENSMUST00000025077.7
    Conserved Domains (2) summary
    cd05402
    Location:209347
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:441486
    PAP_assoc; Cid1 family poly A polymerase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    4375573..4399888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526184.5XP_006526247.1  poly(A) RNA polymerase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006526247.1

    Conserved Domains (2) summary
    cd05402
    Location:2899
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:57248
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

RNA

  1. XR_004939877.1 RNA Sequence

  2. XR_004939879.1 RNA Sequence

  3. XR_004939881.1 RNA Sequence

  4. XR_004939882.1 RNA Sequence

  5. XR_004939880.1 RNA Sequence

  6. XR_004939878.1 RNA Sequence

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