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Retsat retinol saturase (all trans retinol 13,14 reductase) [ Mus musculus (house mouse) ]

Gene ID: 67442, updated on 21-Apr-2024

Summary

Official Symbol
Retsatprovided by MGI
Official Full Name
retinol saturase (all trans retinol 13,14 reductase)provided by MGI
Primary source
MGI:MGI:1914692
See related
Ensembl:ENSMUSG00000056666 AllianceGenome:MGI:1914692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMT-7; Ppsig; 0610039N19Rik
Summary
Enables all-trans-retinol 13,14-reductase activity. Involved in retinol metabolic process. Located in endoplasmic reticulum membrane and nuclear outer membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human RETSAT (retinol saturase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 119.1), kidney adult (RPKM 90.0) and 15 other tissues See more
Orthologs
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Genomic context

Location:
6 C1; 6 32.27 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72575585..72584471)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72598602..72607488)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6442 Neighboring gene capping actin protein, gelsolin like Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4833 Neighboring gene STARR-positive B cell enhancer ABC_E6443 Neighboring gene trans-golgi network protein Neighboring gene predicted gene 15401 Neighboring gene transcription factor 7 like 1 (T cell specific, HMG box)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC143538

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables all-trans-retinol 13,14-reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables all-trans-retinol 13,14-reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables all-trans-retinol 13,14-reductase activity TAS
Traceable Author Statement
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retinol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear outer membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
all-trans-retinol 13,14-reductase
Names
PPAR-alpha-regulated and starvation-induced gene protein
all-trans-13,14-dihydroretinol saturase
NP_080435.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026159.5NP_080435.3  all-trans-retinol 13,14-reductase precursor

    See identical proteins and their annotated locations for NP_080435.3

    Status: VALIDATED

    Source sequence(s)
    AC125039
    Consensus CDS
    CCDS20244.1
    UniProtKB/Swiss-Prot
    Q149J8, Q3UNN9, Q64FW2, Q78JX8, Q8VHE7, Q9CW85
    UniProtKB/TrEMBL
    A4FUU4
    Related
    ENSMUSP00000068568.7, ENSMUST00000070597.13
    Conserved Domains (2) summary
    COG1233
    Location:68566
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
    cl21454
    Location:68568
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72575585..72584471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)