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Plxdc2 plexin domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 67448, updated on 21-Apr-2024

Summary

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Official Symbol
Plxdc2provided by MGI
Official Full Name
plexin domain containing 2provided by MGI
Primary source
MGI:MGI:1914698
See related
Ensembl:ENSMUSG00000026748 AllianceGenome:MGI:1914698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tem7r; 1200007L24Rik; 5430431D22Rik
Summary
Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; inner ear; limb; skin; and trunk mesenchyme. Orthologous to human PLXDC2 (plexin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 9.4), lung adult (RPKM 7.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A2- A3; 2 11.8 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (16360551..16765941)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (16355740..16761132)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene MAM and LDL receptor class A domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_03749 Neighboring gene STARR-seq mESC enhancer starr_03750 Neighboring gene Hmgb1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03751 Neighboring gene STARR-seq mESC enhancer starr_03754 Neighboring gene STARR-seq mESC enhancer starr_03755 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_03757 Neighboring gene STARR-seq mESC enhancer starr_03758 Neighboring gene STARR-seq mESC enhancer starr_03759 Neighboring gene RIKEN cDNA 4930515L03 gene Neighboring gene STARR-seq mESC enhancer starr_03760 Neighboring gene STARR-seq mESC enhancer starr_03761 Neighboring gene STARR-seq mESC enhancer starr_03762 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_03764 Neighboring gene predicted gene, 54103

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of new regulatory genes through expression pattern analysis of a global RNA-seq dataset from a Helicobacter pylori co-culture system. Tubau-Juni N, et al. Sci Rep, 2020 Jul 13. PMID 32661418, Free PMC Article
  2. Plxdc2 is a mitogen for neural progenitors. Miller-Delaney SF, et al. PLoS One, 2011 Jan 21. PMID 21283688, Free PMC Article
  3. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Nanda A, et al. Cancer Res, 2004 Dec 1. PMID 15574754
  4. Expression of Plxdc2/TEM7R in the developing nervous system of the mouse. Miller SF, et al. Gene Expr Patterns, 2007 Apr. PMID 17280871
  5. Cell surface tumor endothelial markers are conserved in mice and humans. Carson-Walter EB, et al. Cancer Res, 2001 Sep 15. PMID 11559528

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of new regulatory genes through expression pattern analysis of a global RNA-seq dataset from a Helicobacter pylori co-culture system.
    Title: Identification of new regulatory genes through expression pattern analysis of a global RNA-seq dataset from a Helicobacter pylori co-culture system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
plexin domain-containing protein 2
Names
tumor endothelial marker 7 related
tumor endothelial marker 7-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026162.6 → NP_080438.2  plexin domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_080438.2

    Status: VALIDATED

    Source sequence(s)
    AK035165, AL928882, AW045408
    Consensus CDS
    CCDS15705.1
    UniProtKB/Swiss-Prot
    Q6PET5, Q91ZV6, Q9DC11
    UniProtKB/TrEMBL
    B1AY86
    Related
    ENSMUSP00000028081.7, ENSMUST00000028081.13
    Conserved Domains (2) summary
    pfam01437
    Location:327 → 372
    PSI; Plexin repeat
    cl02648
    Location:191 → 282
    NIDO; Nidogen-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    16360551..16765941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497531.4 → XP_006497594.1  plexin domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B1AY85, B1AY86
    Related
    ENSMUSP00000110350.2, ENSMUST00000114702.2
    Conserved Domains (2) summary
    pfam01437
    Location:327 → 372
    PSI; Plexin repeat
    cl02648
    Location:191 → 282
    NIDO; Nidogen-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC11.1 GenPept UniProtKB/Swiss-Prot:Q9DC11

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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