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Klhl13 kelch-like 13 [ Mus musculus (house mouse) ]

Gene ID: 67455, updated on 23-Jun-2021

Summary

Official Symbol
Klhl13provided by MGI
Official Full Name
kelch-like 13provided by MGI
Primary source
MGI:MGI:1914705
See related
Ensembl:ENSMUSG00000036782
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bklhd; Bklhd2; AI451128; 1200009K10Rik; D130072F20Rik
Expression
Biased expression in placenta adult (RPKM 72.4), CNS E18 (RPKM 17.0) and 7 other tissues See more
Orthologs
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Genomic context

See Klhl13 in Genome Data Viewer
Location:
X; X A2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (23085510..23231340, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (23219271..23365161, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (22796397..22942179, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1395 Neighboring gene predicted gene, 26131 Neighboring gene WD repeat domain 44 Neighboring gene cyclin-dependent kinase 2 interacting protein pseudogene Neighboring gene testis derived transcript pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kelch-like protein 13
Names
BTB and kelch domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290476.2NP_001277405.1  kelch-like protein 13 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AI451128, AK004677, AL773552
    Consensus CDS
    CCDS72348.1
    UniProtKB/Swiss-Prot
    Q80TF4
    Related
    ENSMUSP00000110974.3, ENSMUST00000115319.9
    Conserved Domains (2) summary
    PHA03098
    Location:85628
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:372420
    Kelch; KELCH repeat [structural motif]
  2. NM_001310466.1NP_001297395.1  kelch-like protein 13 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AI451128, AK004677, AL773552
    Consensus CDS
    CCDS81105.1
    UniProtKB/Swiss-Prot
    Q80TF4
    Related
    ENSMUSP00000110971.3, ENSMUST00000115316.9
    Conserved Domains (2) summary
    PHA03098
    Location:77620
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:364412
    Kelch; KELCH repeat [structural motif]
  3. NM_001381891.1NP_001368820.1  kelch-like protein 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL773552, AL808116
    Conserved Domains (3) summary
    PHA03098
    Location:97640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  4. NM_001381892.1NP_001368821.1  kelch-like protein 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL773552, AL808116
    Conserved Domains (3) summary
    PHA03098
    Location:97640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  5. NM_001381893.1NP_001368822.1  kelch-like protein 13 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL773552
    Conserved Domains (3) summary
    PHA03098
    Location:91634
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:378426
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:68195
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  6. NM_001381894.1NP_001368823.1  kelch-like protein 13 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL773552
    Related
    ENSMUSP00000110972.3, ENSMUST00000115317.9
    Conserved Domains (3) summary
    PHA03098
    Location:91634
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:378426
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:68195
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  7. NM_001381895.1NP_001368824.1  kelch-like protein 13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL773552, AL808116
    Conserved Domains (3) summary
    PHA03098
    Location:75618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  8. NM_001381896.1NP_001368825.1  kelch-like protein 13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL773552, AL808116
    Related
    ENSMUSP00000041190.5, ENSMUST00000035973.5
    Conserved Domains (3) summary
    PHA03098
    Location:75618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  9. NM_026167.4NP_080443.1  kelch-like protein 13 isoform 1

    See identical proteins and their annotated locations for NP_080443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (1).
    Source sequence(s)
    AI451128, AK004677, BY136647
    Consensus CDS
    CCDS40891.1
    UniProtKB/Swiss-Prot
    Q80TF4
    Conserved Domains (3) summary
    PHA03098
    Location:75618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    23085510..23231340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251489.2XP_030107349.1  kelch-like protein 13 isoform X1

    Conserved Domains (3) summary
    PHA03098
    Location:97640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  2. XM_011247487.3XP_011245789.1  kelch-like protein 13 isoform X1

    See identical proteins and their annotated locations for XP_011245789.1

    Conserved Domains (3) summary
    PHA03098
    Location:97640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  3. XM_011247492.4XP_011245794.1  kelch-like protein 13 isoform X4

    See identical proteins and their annotated locations for XP_011245794.1

    UniProtKB/Swiss-Prot
    Q80TF4
    Conserved Domains (3) summary
    PHA03098
    Location:75618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  4. XM_036162081.1XP_036017974.1  kelch-like protein 13 isoform X4

    Conserved Domains (3) summary
    PHA03098
    Location:75618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  5. XM_036162080.1XP_036017973.1  kelch-like protein 13 isoform X4

    Conserved Domains (3) summary
    PHA03098
    Location:75618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  6. XM_011247488.4XP_011245790.1  kelch-like protein 13 isoform X2

    Conserved Domains (3) summary
    PHA03098
    Location:94637
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:381429
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:71198
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  7. XM_036162082.1XP_036017975.1  kelch-like protein 13 isoform X5

    Related
    ENSMUSP00000110968.2, ENSMUST00000115313.8
    Conserved Domains (3) summary
    PHA03098
    Location:41584
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:328376
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:18145
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
  8. XM_030251491.2XP_030107351.1  kelch-like protein 13 isoform X3

    Conserved Domains (3) summary
    PHA03098
    Location:91634
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:378426
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:68195
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
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