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Larp6 La ribonucleoprotein 6, translational regulator [ Mus musculus (house mouse) ]

Gene ID: 67557, updated on 21-Apr-2024

Summary

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Official Symbol
Larp6provided by MGI
Official Full Name
La ribonucleoprotein 6, translational regulatorprovided by MGI
Primary source
MGI:MGI:1914807
See related
Ensembl:ENSMUSG00000034839 AllianceGenome:MGI:1914807
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Achn; 5430431G03Rik
Summary
Predicted to enable RNA binding activity and myosin binding activity. Predicted to be involved in positive regulation of collagen biosynthetic process; positive regulation of mRNA binding activity; and positive regulation of translation. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of polysome. Predicted to be active in nucleus. Is expressed in brain; dorsal root ganglion; facial ganglion; and trigeminal ganglion. Orthologous to human LARP6 (La ribonucleoprotein 6, translational regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 12.1), cortex adult (RPKM 9.2) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 32.87 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (60620404..60646084)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (60713121..60738801)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene annexin A7 pseudogene Neighboring gene leucine rich repeat containing 49 Neighboring gene STARR-seq mESC enhancer starr_24323 Neighboring gene STARR-seq mESC enhancer starr_24324 Neighboring gene RIKEN cDNA 1700036A12 gene Neighboring gene STARR-seq mESC enhancer starr_24325 Neighboring gene STARR-seq mESC enhancer starr_24327 Neighboring gene uveal autoantigen with coiled-coil domains and ankyrin repeats Neighboring gene predicted gene 9869

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6. Zuo S, et al. EMBO J, 2021 Aug 16. PMID 34223653, Free PMC Article
  2. Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression. Guo Y, et al. Dev Growth Differ, 2017 Feb. PMID 28211947
  3. The novel lupus antigen related protein acheron enhances the development of human breast cancer. Shao R, et al. Int J Cancer, 2012 Feb 1. PMID 21387291, Free PMC Article
  4. Regulation of muscle differentiation and survival by Acheron. Wang Z, et al. Mech Dev, 2009 Aug-Sep. PMID 19481601
  5. Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta. Valavanis C, et al. Gene, 2007 May 15. PMID 17383118, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that insulin-like growth factor 1 (IGF1) could promote collagen I alpha 2 (COL1A2) expression and osteoblast differentiation in primary pre-osteoblasts by increasing La ribonucleoprotein domain family member 6 (Larp6) expression via a posttranscriptional mechanism.
    Title: Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression.
  2. LARP6 is a critical mediator by which IGF-1 augments synthesis of collagen type I in vascular smooth muscle
    Title: Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA.
  3. Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
    Title: Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
  4. Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization.
    Title: The novel lupus antigen related protein acheron enhances the development of human breast cancer.
  5. achn plays key roles in the processes of differentiation and self-renewal
    Title: Regulation of muscle differentiation and survival by Acheron.
  6. These data define Achn as a newly discovered regulatory molecule that presumably mediates a variety of developmental and homeostatic processes in animals.
    Title: Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC115805

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
la-related protein 6
Names
La ribonucleoprotein domain family, member 6
acheron

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026235.4 → NP_080511.2  la-related protein 6

    See identical proteins and their annotated locations for NP_080511.2

    Status: PROVISIONAL

    Source sequence(s)
    AC156940
    Consensus CDS
    CCDS23258.1
    UniProtKB/Swiss-Prot
    Q8BN59, Q8C9A3, Q8CA51, Q9CTN3, Q9D3J0
    Related
    ENSMUSP00000040309.6, ENSMUST00000038407.6
    Conserved Domains (3) summary
    cd08033
    Location:93 → 169
    LARP_6; La RNA-binding domain of La-related protein 6
    cd12289
    Location:184 → 292
    RRM_LARP6; RNA recognition motif in La-related protein 6 (LARP6) and similar proteins
    pfam12901
    Location:468 → 482
    SUZ-C; SUZ-C motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    60620404..60646084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BN59.1 GenPept UniProtKB/Swiss-Prot:Q8BN59

Gene LinkOut

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