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Trmt112 tRNA methyltransferase 11-2 [ Mus musculus (house mouse) ]

Gene ID: 67674, updated on 5-Mar-2024

Summary

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Official Symbol
Trmt112provided by MGI
Official Full Name
tRNA methyltransferase 11-2provided by MGI
Primary source
MGI:MGI:1914924
See related
Ensembl:ENSMUSG00000038812 AllianceGenome:MGI:1914924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trm112p; 0610038D11Rik
Summary
Predicted to enable protein heterodimerization activity and protein methyltransferase activity. Involved in peptidyl-glutamine methylation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Is expressed in several structures, including brain; gut; limb bud; lung; and sensory organ. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 69.5), adrenal adult (RPKM 52.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.08 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6887066..6888396)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6909698..6911028)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 88B Neighboring gene predicted gene, 54051 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6946569-6946770 Neighboring gene peroxiredoxin 5 Neighboring gene estrogen related receptor, alpha Neighboring gene microRNA 6990 Neighboring gene STARR-positive B cell enhancer ABC_E780 Neighboring gene cation channel sperm associated auxiliary subunit zeta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Trmt112 gene expression in mouse embryonic development. Gu T, et al. Acta Histochem Cytochem, 2012 Apr 26. PMID 22685353, Free PMC Article
  2. Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates. Kusevic D, et al. J Biol Chem, 2016 Mar 18. PMID 26797129, Free PMC Article
  3. HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1. Figaro S, et al. FEBS Lett, 2008 Jul 9. PMID 18539146
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables tRNA methyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-glutamine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-glutamine methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-glutamine methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA (guanine-N7)-methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA (guanine-N7)-methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
multifunctional methyltransferase subunit TRM112-like protein
Names
TRM112-like protein
tRNA methyltransferase 11-2 homolog
tRNA methyltransferase 112 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166370.1 → NP_001159842.1  multifunctional methyltransferase subunit TRM112-like protein

    See identical proteins and their annotated locations for NP_001159842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer and more frequently occurring transcript. Both variants encode the same protein.
    Source sequence(s)
    BC087959, BE951374, DV654053
    Consensus CDS
    CCDS29508.1
    UniProtKB/Swiss-Prot
    Q91YP8, Q9D1N6, Q9DCG9
    UniProtKB/TrEMBL
    Q5M8M3
    Related
    ENSMUSP00000112250.4, ENSMUST00000116551.10
    Conserved Domains (1) summary
    pfam03966
    Location:86 → 112
    Trm112p; Trm112p-like protein

  2. NM_026306.3 → NP_080582.3  multifunctional methyltransferase subunit TRM112-like protein

    See identical proteins and their annotated locations for NP_080582.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    BC087959, BE951374
    Consensus CDS
    CCDS29508.1
    UniProtKB/Swiss-Prot
    Q91YP8, Q9D1N6, Q9DCG9
    UniProtKB/TrEMBL
    Q5M8M3
    Related
    ENSMUSP00000085591.8, ENSMUST00000088257.14
    Conserved Domains (1) summary
    pfam03966
    Location:86 → 112
    Trm112p; Trm112p-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6887066..6888396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCG9.1 GenPept UniProtKB/Swiss-Prot:Q9DCG9

Gene LinkOut

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