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Plgrkt plasminogen receptor, C-terminal lysine transmembrane protein [ Mus musculus (house mouse) ]

Gene ID: 67759, updated on 5-Mar-2024

Summary

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Official Symbol
Plgrktprovided by MGI
Official Full Name
plasminogen receptor, C-terminal lysine transmembrane proteinprovided by MGI
Primary source
MGI:MGI:1915009
See related
Ensembl:ENSMUSG00000016495 AllianceGenome:MGI:1915009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plg-RKT; Plg-R(KT); 1110007H22Rik; 5033414D02Rik
Summary
Acts upstream of or within positive regulation of plasminogen activation. Is integral component of plasma membrane. Is expressed in thymus primordium. Orthologous to human PLGRKT (plasminogen receptor with a C-terminal lysine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 21.8), thymus adult (RPKM 10.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Plgrkt in Genome Data Viewer
Location:
19 C1; 19 23.85 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29326004..29339340, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29348599..29367292, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene insulin-like 6 Neighboring gene predicted gene, 52390 Neighboring gene relaxin 1 Neighboring gene STARR-positive B cell enhancer ABC_E9996 Neighboring gene STARR-positive B cell enhancer ABC_E3250 Neighboring gene STARR-positive B cell enhancer ABC_E5694 Neighboring gene CD274 antigen Neighboring gene predicted gene, 36043 Neighboring gene STARR-positive B cell enhancer mm9_chr19:29465786-29466087 Neighboring gene STARR-seq mESC enhancer starr_45884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29493177-29493330 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene STARR-positive B cell enhancer mm9_chr19:29505524-29505825 Neighboring gene STARR-seq mESC enhancer starr_45885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29528717-29528916

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The plasminogen receptor Plg-R(KT) regulates adipose function and metabolic homeostasis. Samad F, et al. J Thromb Haemost, 2022 Mar. PMID 34897983, Free PMC Article
  2. Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets. Whyte CS, et al. Blood, 2021 Jan 14. PMID 32842150, Free PMC Article
  3. The plasminogen receptor(,) Plg-R(KT)(,) is essential for mammary lobuloalveolar development and lactation. Miles LA, et al. J Thromb Haemost, 2018 May. PMID 29495105, Free PMC Article
  4. Deficiency of plasminogen receptor, Plg-R(KT) , causes defects in plasminogen binding and inflammatory macrophage recruitment in vivo. Miles LA, et al. J Thromb Haemost, 2017 Jan. PMID 27714956, Free PMC Article
  5. The plasminogen receptor, Plg-R(KT), plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice. Ny L, et al. Cell Death Dis, 2020 Dec 12. PMID 33311441, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The plasminogen receptor Plg-RKT regulates adipose function and metabolic homeostasis.
    Title: The plasminogen receptor Plg-R(KT) regulates adipose function and metabolic homeostasis.
  2. Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
    Title: Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
  3. The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice.
    Title: The plasminogen receptor, Plg-R(KT), plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice.
  4. Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes.
    Title: Plasminogen and the Plasminogen Receptor, Plg-R(KT), Regulate Macrophage Phenotypic, and Functional Changes.
  5. Plg-RKT is essential for lactogenesis and functions to maintain the appropriate stromal extracellular matrix environment, regulate epithelial cell proliferation and apoptosis, and, by regulating fibrinolysis, preserve alveolar and ductal patency.
    Title: The plasminogen receptor(,) Plg-R(KT)(,) is essential for mammary lobuloalveolar development and lactation.
  6. Plg-R(KT) was highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 pheochromocytoma cells, and murine hippocampus.
    Title: The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release.
  7. Plg-R(KT) plays a key role in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response.
    Title: Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of plasminogen activation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
plasminogen receptor (KT)
Names
transmembrane protein C9orf46 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026362.2 → NP_080638.1  plasminogen receptor (KT)

    See identical proteins and their annotated locations for NP_080638.1

    Status: VALIDATED

    Source sequence(s)
    AK017215
    Consensus CDS
    CCDS29734.1
    UniProtKB/Swiss-Prot
    Q3TCJ3, Q9D3P8
    Related
    ENSMUSP00000120466.2, ENSMUST00000143467.8
    Conserved Domains (1) summary
    pfam10166
    Location:1 → 134
    DUF2368; Uncharacterized conserved protein (DUF2368)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    29326004..29339340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251060.2 → XP_030106920.1  plasminogen receptor (KT) isoform X1

    UniProtKB/Swiss-Prot
    Q3TCJ3, Q9D3P8
    Conserved Domains (1) summary
    pfam10166
    Location:1 → 134
    DUF2368; Uncharacterized conserved protein (DUF2368)

  2. XM_030251059.2 → XP_030106919.1  plasminogen receptor (KT) isoform X1

    UniProtKB/Swiss-Prot
    Q3TCJ3, Q9D3P8
    Related
    ENSMUSP00000016639.6, ENSMUST00000016639.12
    Conserved Domains (1) summary
    pfam10166
    Location:1 → 134
    DUF2368; Uncharacterized conserved protein (DUF2368)

  3. XM_030251058.2 → XP_030106918.1  plasminogen receptor (KT) isoform X1

    UniProtKB/Swiss-Prot
    Q3TCJ3, Q9D3P8
    Conserved Domains (1) summary
    pfam10166
    Location:1 → 134
    DUF2368; Uncharacterized conserved protein (DUF2368)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3P8.1 GenPept UniProtKB/Swiss-Prot:Q9D3P8

Gene LinkOut

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