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Rtp4 receptor transporter protein 4 [ Mus musculus (house mouse) ]

Gene ID: 67775, updated on 2-Apr-2024

Summary

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Official Symbol
Rtp4provided by MGI
Official Full Name
receptor transporter protein 4provided by MGI
Primary source
MGI:MGI:1915025
See related
Ensembl:ENSMUSG00000033355 AllianceGenome:MGI:1915025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifrg28; 5830458K16Rik
Summary
Predicted to enable olfactory receptor binding activity. Predicted to be involved in defense response to virus; detection of chemical stimulus involved in sensory perception of bitter taste; and establishment of protein localization to membrane. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Orthologous to human RTP4 (receptor transporter protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 8.8), mammary gland adult (RPKM 5.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B1; 16 14.55 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (23338976..23432972)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23520219..23614222)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40441 Neighboring gene receptor transporter protein 1 Neighboring gene STARR-seq mESC enhancer starr_40442 Neighboring gene MBL associated serine protease 1 Neighboring gene VISTA enhancer mm1315 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene STARR-seq mESC enhancer starr_40444 Neighboring gene STARR-seq mESC enhancer starr_40445 Neighboring gene STARR-seq mESC enhancer starr_40448 Neighboring gene ATP-binding cassette, sub-family E (OABP), member 1 pseudogene Neighboring gene predicted gene, 31430

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine. Fujita W, et al. Biomolecules, 2022 Oct 13. PMID 36291680, Free PMC Article
  2. Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine. Fujita W, et al. Mol Pharmacol, 2019 Jan. PMID 30348895, Free PMC Article
  3. RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology. He X, et al. Proc Natl Acad Sci U S A, 2020 Aug 11. PMID 32709745, Free PMC Article
  4. Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Décaillot FM, et al. Proc Natl Acad Sci U S A, 2008 Oct 14. PMID 18836069, Free PMC Article
  5. RTP family members induce functional expression of mammalian odorant receptors. Saito H, et al. Cell, 2004 Nov 24. PMID 15550249

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4).
    Title: Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4).
  2. Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine.
    Title: Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine.
  3. RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology.
    Title: RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology.
  4. Selective MOPr-mediated increase in RTP4 expression.
    Title: Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine.
  5. RTP4, a Golgi chaperone, is a regulator of the levels of heterodimers at the cell surface; association with RTP4 protects mu-delta receptors from ubiquitination and degradation
    Title: Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of chemical stimulus involved in sensory perception of bitter taste ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor-transporting protein 4
Names
28 kDa interferon-responsive protein
28kD interferon alpha responsive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023386.6 → NP_075875.3  receptor-transporting protein 4

    See identical proteins and their annotated locations for NP_075875.3

    Status: VALIDATED

    Source sequence(s)
    AC217053
    Consensus CDS
    CCDS28079.1
    UniProtKB/Swiss-Prot
    Q9D3D6, Q9ER80
    UniProtKB/TrEMBL
    Q8R3Q4
    Related
    ENSMUSP00000041091.6, ENSMUST00000038423.6
    Conserved Domains (1) summary
    pfam13695
    Location:51 → 162
    zf-3CxxC; Zinc-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    23338976..23432972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160102.1 → XP_036015995.1  receptor-transporting protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9D3D6, Q9ER80
    UniProtKB/TrEMBL
    Q8R3Q4
    Conserved Domains (1) summary
    pfam13695
    Location:51 → 162
    zf-3CxxC; Zinc-binding domain

  2. XM_030249256.2 → XP_030105116.1  receptor-transporting protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9D3D6, Q9ER80
    UniProtKB/TrEMBL
    Q8R3Q4
    Related
    ENSMUSP00000147521.2, ENSMUST00000209422.2
    Conserved Domains (1) summary
    pfam13695
    Location:51 → 162
    zf-3CxxC; Zinc-binding domain

  3. XM_006522491.5 → XP_006522554.1  receptor-transporting protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006522554.1

    UniProtKB/Swiss-Prot
    Q9D3D6, Q9ER80
    UniProtKB/TrEMBL
    Q8R3Q4
    Conserved Domains (1) summary
    pfam13695
    Location:51 → 162
    zf-3CxxC; Zinc-binding domain

  4. XM_030249257.2 → XP_030105117.1  receptor-transporting protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9D3D6, Q9ER80
    UniProtKB/TrEMBL
    Q8R3Q4
    Related
    ENSMUSP00000147442.2, ENSMUST00000210901.2
    Conserved Domains (1) summary
    pfam13695
    Location:51 → 162
    zf-3CxxC; Zinc-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER80.1 GenPept UniProtKB/Swiss-Prot:Q9ER80

Gene LinkOut

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