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Ubxn4 UBX domain protein 4 [ Mus musculus (house mouse) ]

Gene ID: 67812, updated on 11-Apr-2024

Summary

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Official Symbol
Ubxn4provided by MGI
Official Full Name
UBX domain protein 4provided by MGI
Primary source
MGI:MGI:1915062
See related
Ensembl:ENSMUSG00000026353 AllianceGenome:MGI:1915062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubxd2; mKIAA0242; 1300013G12Rik
Summary
Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in cytosol and endoplasmic reticulum. Is expressed in embryo. Orthologous to human UBXN4 (UBX domain protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 17.2), CNS E14 (RPKM 13.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E3; 1 55.8 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (128171635..128207115)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (128243898..128279378)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene male-enhanced antigen 1 pseudogene Neighboring gene R3H domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02158 Neighboring gene microRNA 128-1 Neighboring gene STARR-seq mESC enhancer starr_02159 Neighboring gene STARR-positive B cell enhancer ABC_E9060 Neighboring gene predicted gene, 41949 Neighboring gene lactase Neighboring gene STARR-positive B cell enhancer ABC_E7743 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130255918-130256027 Neighboring gene STARR-positive B cell enhancer ABC_E2006 Neighboring gene minichromosome maintenance complex component 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. Aweida D, et al. EMBO Rep, 2022 Dec 6. PMID 36278411, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0242

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UBX domain-containing protein 4
Names
UBX domain containing 2
UBX domain-containing protein 2
erasin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356529.1 → NP_001343458.1  UBX domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161809
    UniProtKB/Swiss-Prot
    Q3UGR4, Q8BW17, Q8VCH8
    Conserved Domains (2) summary
    smart00166
    Location:319 → 394
    UBX; Domain present in ubiquitin-regulatory proteins
    cl00388
    Location:4 → 113
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  2. NM_026390.3 → NP_080666.2  UBX domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_080666.2

    Status: VALIDATED

    Source sequence(s)
    AC161809, AK029431, AK075716, AK147795, AK148889, BQ745792
    Consensus CDS
    CCDS15251.1
    UniProtKB/Swiss-Prot
    Q3UGR4, Q8BW17, Q8VCH8
    UniProtKB/TrEMBL
    A0A0R4J078
    Related
    ENSMUSP00000027592.4, ENSMUST00000027592.6
    Conserved Domains (2) summary
    smart00166
    Location:318 → 393
    UBX; Domain present in ubiquitin-regulatory proteins
    cl00388
    Location:4 → 113
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    128171635..128207115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529831.2 → XP_006529894.1  UBX domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q3UGR4, Q8BW17, Q8VCH8
    Conserved Domains (2) summary
    cl00388
    Location:4 → 113
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl28922
    Location:318 → 355
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_017322239.1 → XP_017177728.1  UBX domain-containing protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q3UGR4, Q8BW17, Q8VCH8
    Conserved Domains (2) summary
    cl00388
    Location:4 → 113
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl28922
    Location:317 → 354
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCH8.1 GenPept UniProtKB/Swiss-Prot:Q8VCH8

Gene LinkOut

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