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Derl1 Der1-like domain family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 67819, updated on 23-Jun-2021

Summary

Official Symbol
Derl1provided by MGI
Official Full Name
Der1-like domain family, member 1provided by MGI
Primary source
MGI:MGI:1915069
See related
Ensembl:ENSMUSG00000022365
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Derl; AI195141; AW551338; Derlin-1; 1110021N07Rik
Expression
Ubiquitous expression in adrenal adult (RPKM 131.2), mammary gland adult (RPKM 73.3) and 28 other tissues See more
Orthologs
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Genomic context

See Derl1 in Genome Data Viewer
Location:
15; 15 D1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57732898..57755814, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (57869502..57892418, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (57701057..57723973, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35682 Neighboring gene predicted gene, 35771 Neighboring gene zinc fingers and homeoboxes 2 Neighboring gene TBC1 domain family, member 31 Neighboring gene uncharacterized LOC115488500 Neighboring gene nuclear encoded tRNA methionine 16 (anticodon CAT)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signal recognition particle binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-specific protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ER-associated misfolded protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex ISO
Inferred from Sequence Orthology
more info
 
part_of Derlin-1-VIMP complex ISO
Inferred from Sequence Orthology
more info
 
part_of Hrd1p ubiquitin ligase ERAD-L complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum quality control compartment IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
derlin-1
Names
degradation in endoplasmic reticulum protein 1
der1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024207.4NP_077169.1  derlin-1

    See identical proteins and their annotated locations for NP_077169.1

    Status: PROVISIONAL

    Source sequence(s)
    AC154874
    Consensus CDS
    CCDS27484.1
    UniProtKB/Swiss-Prot
    Q99J56
    Related
    ENSMUSP00000022993.6, ENSMUST00000022993.7
    Conserved Domains (1) summary
    pfam04511
    Location:11204
    DER1; Der1-like family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    57732898..57755814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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