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Gpsm1 G-protein signalling modulator 1 (AGS3-like, C. elegans) [ Mus musculus (house mouse) ]

Gene ID: 67839, updated on 11-Jul-2021

Summary

Official Symbol
Gpsm1provided by MGI
Official Full Name
G-protein signalling modulator 1 (AGS3-like, C. elegans)provided by MGI
Primary source
MGI:MGI:1915089
See related
Ensembl:ENSMUSG00000026930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ag; Ags3; AW107933; 1810037C22Rik
Expression
Broad expression in ovary adult (RPKM 24.9), whole brain E14.5 (RPKM 24.0) and 24 other tissues See more
Orthologs
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Genomic context

See Gpsm1 in Genome Data Viewer
Location:
2; 2 A3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26204623..26238249)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26314611..26348237)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (26171060..26203755)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52504 Neighboring gene coiled-coil domain containing 187 Neighboring gene predicted gene, 35807 Neighboring gene predicted gene, 52505 Neighboring gene predicted gene 13562 Neighboring gene DNL-type zinc finger Neighboring gene caspase recruitment domain family, member 9 Neighboring gene small nuclear RNA activating complex, polypeptide 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G-protein-signaling modulator 1
Names
activator of G-protein signaling 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199146.1NP_001186075.1  G-protein-signaling modulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001186075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' terminus which results in the use of an alternate tranlation initiation site and lacks an in-frame exon at the 3' end, compared to variant 3. Variant 2 encodes isoform 2 which has a shorter and distinct N-terminus, compared to isoform 3.
    Source sequence(s)
    AK084631, BC071197, CA317518
    Consensus CDS
    CCDS57158.1
    UniProtKB/Swiss-Prot
    Q6IR34
    Related
    ENSMUSP00000077686.6, ENSMUST00000078616.12
    Conserved Domains (6) summary
    smart00390
    Location:534556
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    sd00006
    Location:207234
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:106138
    TPR_1; Tetratricopeptide repeat
    pfam02188
    Location:434455
    GoLoco; GoLoco motif
    pfam13176
    Location:288322
    TPR_7; Tetratricopeptide repeat
    pfam13424
    Location:207278
    TPR_12; Tetratricopeptide repeat
  2. NM_001199147.1NP_001186076.1  G-protein-signaling modulator 1 isoform 3

    See identical proteins and their annotated locations for NP_001186076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    BC071197, CK618701
    Consensus CDS
    CCDS57159.1
    UniProtKB/Swiss-Prot
    Q6IR34
    Related
    ENSMUSP00000067964.7, ENSMUST00000066889.13
    Conserved Domains (6) summary
    smart00390
    Location:626648
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    sd00006
    Location:239266
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:138170
    TPR_1; Tetratricopeptide repeat
    pfam02188
    Location:526547
    GoLoco; GoLoco motif
    pfam13176
    Location:320354
    TPR_7; Tetratricopeptide repeat
    pfam13424
    Location:239310
    TPR_12; Tetratricopeptide repeat
  3. NM_001355574.1NP_001342503.1  G-protein-signaling modulator 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL732541
    Conserved Domains (5) summary
    smart00390
    Location:571593
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    COG0457
    Location:37335
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:184211
    TPR; TPR repeat [structural motif]
    pfam02188
    Location:471492
    GoLoco; GoLoco motif
    pfam13424
    Location:184255
    TPR_12; Tetratricopeptide repeat
  4. NM_001355575.1NP_001342504.1  G-protein-signaling modulator 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL732541
    Related
    ENSMUSP00000115680.2, ENSMUST00000145884.8
    Conserved Domains (4) summary
    COG0457
    Location:66237
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:86113
    TPR; TPR repeat [structural motif]
    pfam02188
    Location:373394
    GoLoco; GoLoco motif
    pfam13424
    Location:86157
    TPR_12; Tetratricopeptide repeat
  5. NM_001355576.1NP_001342505.1  G-protein-signaling modulator 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL732541
    Conserved Domains (5) summary
    smart00390
    Location:511533
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    COG0457
    Location:27335
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:184211
    TPR; TPR repeat [structural motif]
    pfam02188
    Location:411432
    GoLoco; GoLoco motif
    pfam13424
    Location:184255
    TPR_12; Tetratricopeptide repeat
  6. NM_153410.5NP_700459.2  G-protein-signaling modulator 1 isoform 1

    See identical proteins and their annotated locations for NP_700459.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' terminus which results in the use of an alternate tranlation initiation site, compared to variant 3. Variant 1 encodes isoform 1 which has a shorter and distinct N-terminus, compared to isoform 3.
    Source sequence(s)
    AK048691, BC071197, CA317518
    Consensus CDS
    CCDS15800.1
    UniProtKB/Swiss-Prot
    Q6IR34
    Related
    ENSMUSP00000065000.3, ENSMUST00000066936.9
    Conserved Domains (6) summary
    smart00390
    Location:594616
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    sd00006
    Location:207234
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:106138
    TPR_1; Tetratricopeptide repeat
    pfam02188
    Location:494515
    GoLoco; GoLoco motif
    pfam13176
    Location:288322
    TPR_7; Tetratricopeptide repeat
    pfam13424
    Location:207278
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26204623..26238249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162509.1XP_036018402.1  G-protein-signaling modulator 1 isoform X2

    Related
    ENSMUSP00000109769.3, ENSMUST00000114134.9
    Conserved Domains (1) summary
    pfam02188
    Location:5776
    GoLoco; GoLoco motif
  2. XM_036162508.1XP_036018401.1  G-protein-signaling modulator 1 isoform X1

    Conserved Domains (1) summary
    pfam02188
    Location:117136
    GoLoco; GoLoco motif
  3. XM_006498255.3XP_006498318.1  G-protein-signaling modulator 1 isoform X3

    Conserved Domains (1) summary
    pfam02188
    Location:4160
    GoLoco; GoLoco motif

RNA

  1. XR_003953699.2 RNA Sequence

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