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Haus8l2 HAUS augmin-like complex, subunit 8 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680121, updated on 11-Apr-2024

Summary

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Official Symbol
Haus8l2provided by RGD
Official Full Name
HAUS augmin-like complex, subunit 8 like 2provided by RGD
Primary source
RGD:1595502
See related
AllianceGenome:RGD:1595502
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and clathrin-uncoating ATPase activity. Predicted to be involved in several processes, including chaperone cofactor-dependent protein refolding; chaperone-mediated autophagy translocation complex disassembly; and late endosomal microautophagy. Predicted to be active in several cellular components, including postsynaptic cytosol; presynaptic cytosol; and vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
11p12
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (19074905..19077014)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (5628432..5630535)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (13499168..13501271)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 5 Neighboring gene cell adhesion molecule 2 Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 7 Neighboring gene arginine and serine rich coiled-coil 1, pseudogene 2 Neighboring gene uncharacterized LOC120095556

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent protein disaggregase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables C3HC4-type RING finger domain binding IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin coat disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosomal microautophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of supramolecular fiber organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation by host of viral genome replication IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Prp19 complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in glycinergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor ribbon synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein folding chaperone complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heat shock cognate 71 kDa protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    19074905..19077014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088763.2 → XP_038944691.1  heat shock cognate 71 kDa protein-like

    UniProtKB/TrEMBL
    D4A4S3
    Conserved Domains (1) summary
    PTZ00009
    Location:1 → 613
    PTZ00009; heat shock 70 kDa protein; Provisional
Nucleotide Protein Strain
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