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Psca prostate stem cell antigen [ Rattus norvegicus (Norway rat) ]

Gene ID: 680210, updated on 13-Apr-2024

Summary

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Gene symbol
Psca
Gene description
prostate stem cell antigen
See related
Ensembl:ENSRNOG00000061376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Kidney (RPKM 120.8) and Testes (RPKM 82.7) See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (108483974..108492098)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (106598203..106603114)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116090189..116091955)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479925 Neighboring gene U6 spliceosomal RNA Neighboring gene activity-regulated cytoskeleton-associated protein Neighboring gene Jrk helix-turn-helix protein Neighboring gene thioesterase superfamily member 6 Neighboring gene secreted Ly6/Plaur domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In utero and lactational exposure of DEHP increases the susceptibility of prostate carcinogenesis in male offspring through PSCA hypomethylation. Xia B, et al. Toxicol Lett, 2018 Aug. PMID 29689378
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypomethylation of PSCA could mediate the effect of di(2-ethylhexyl) phthalate on prostate carcinogenesis in rats.
    Title: In utero and lactational exposure of DEHP increases the susceptibility of prostate carcinogenesis in male offspring through PSCA hypomethylation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

General protein information

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Preferred Names
prostate stem cell antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172106.3 → NP_001165577.1  prostate stem cell antigen precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6A8F0, D4A6I7
    Related
    ENSRNOP00000070961.1, ENSRNOT00000081571.2
    Conserved Domains (1) summary
    cd00117
    Location:21 → 95
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    108483974..108492098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264246.1 → XP_063120316.1  prostate stem cell antigen isoform X1

  2. XM_039079881.2 → XP_038935809.1  prostate stem cell antigen isoform X3

    UniProtKB/TrEMBL
    A0A8I6A8F0, D4A6I7
    Conserved Domains (1) summary
    cd00117
    Location:21 → 95
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  3. XM_017595109.3 → XP_017450598.1  prostate stem cell antigen isoform X2

    UniProtKB/TrEMBL
    A0A8I6A8F0
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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