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Pknox2 PBX/knotted 1 homeobox 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680549, updated on 7-May-2024

Summary

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Official Symbol
Pknox2provided by RGD
Official Full Name
PBX/knotted 1 homeobox 2provided by RGD
Primary source
RGD:1590611
See related
Ensembl:ENSRNOG00000028856 AllianceGenome:RGD:1590611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and actin binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytoskeleton; intercellular bridge; and nucleoplasm. Orthologous to human PKNOX2 (PBX/knotted 1 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 66.8), Brain (RPKM 46.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pknox2 in Genome Data Viewer
Location:
8q22
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (44789464..45051933, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (36600633..36863131, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39361698..39551700, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene 60S ribosomal protein L14 pseudogene Neighboring gene uncharacterized LOC120094114 Neighboring gene uncharacterized LOC108351675 Neighboring gene transmembrane protein 218 Neighboring gene solute carrier family 37 member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export. Haller K, et al. J Biol Chem, 2004 Nov 19. PMID 15339927
  2. Prep2: cloning and expression of a new prep family member. Haller K, et al. Dev Dyn, 2002 Nov. PMID 12412021
  3. Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Ferretti E, et al. Mol Cell Biol, 2006 Aug. PMID 16847320, Free PMC Article
  4. Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Zhang X, et al. Dev Biol, 2006 Dec 15. PMID 17049510
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
homeobox protein PKNOX2
Names
homeobox protein Meis2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271278.1 → NP_001258207.1  homeobox protein PKNOX2 isoform 1

    See identical proteins and their annotated locations for NP_001258207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Related
    ENSRNOP00000070748.2, ENSRNOT00000091894.2
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  2. NM_001271279.1 → NP_001258208.1  homeobox protein PKNOX2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the 5' UTR and an additional exon in the 5' coding region, which results in a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A096MJK1
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    44789464..45051933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082146.2 → XP_038938074.1  homeobox protein PKNOX2 isoform X3

    Conserved Domains (3) summary
    pfam05920
    Location:194 → 229
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  2. XM_039082131.2 → XP_038938059.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  3. XM_039082142.2 → XP_038938070.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  4. XM_039082143.2 → XP_038938071.1  homeobox protein PKNOX2 isoform X2

    UniProtKB/TrEMBL
    A0A096MJK1
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  5. XM_063266117.1 → XP_063122187.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3

  6. XM_039082133.2 → XP_038938061.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  7. XM_039082132.2 → XP_038938060.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  8. XM_063266115.1 → XP_063122185.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3

  9. XM_063266119.1 → XP_063122189.1  homeobox protein PKNOX2 isoform X2

    UniProtKB/TrEMBL
    A0A096MJK1

  10. XM_039082135.2 → XP_038938063.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  11. XM_039082136.2 → XP_038938064.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  12. XM_039082137.2 → XP_038938065.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  13. XM_063266120.1 → XP_063122190.1  homeobox protein PKNOX2 isoform X2

    UniProtKB/TrEMBL
    A0A096MJK1

  14. XM_039082139.2 → XP_038938067.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  15. XM_039082138.2 → XP_038938066.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  16. XM_063266116.1 → XP_063122186.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3

  17. XM_039082134.2 → XP_038938062.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  18. XM_039082140.2 → XP_038938068.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ2, A6KRM3
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  19. XM_039082145.2 → XP_038938073.1  homeobox protein PKNOX2 isoform X2

    UniProtKB/TrEMBL
    A0A096MJK1
    Related
    ENSRNOP00000068159.2
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  20. XM_063266121.1 → XP_063122191.1  homeobox protein PKNOX2 isoform X4

  21. XM_039082148.1 → XP_038938076.1  homeobox protein PKNOX2 isoform X4

    Conserved Domains (3) summary
    pfam05920
    Location:173 → 212
    Homeobox_KN; Homeobox KN domain
    pfam10018
    Location:134 → 229
    Med4; Vitamin-D-receptor interacting Mediator subunit 4
    pfam16493
    Location:1 → 48
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
Nucleotide Protein Strain
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