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Slc25a39 solute carrier family 25, member 39 [ Mus musculus (house mouse) ]

Gene ID: 68066, updated on 21-Apr-2024

Summary

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Official Symbol
Slc25a39provided by MGI
Official Full Name
solute carrier family 25, member 39provided by MGI
Primary source
MGI:MGI:1196386
See related
Ensembl:ENSMUSG00000018677 AllianceGenome:MGI:1196386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D11Ertd333e; 3010027G13Rik
Summary
Predicted to act upstream of or within heme biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and skeleton. Orthologous to human SLC25A39 (solute carrier family 25 member 39). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 285.8), kidney adult (RPKM 222.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 66.29 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102293795..102299501, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102402969..102408675, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Bloodlinc, erythroid developmental long intergenic non-protein coding transcript Neighboring gene predicted gene, 34253 Neighboring gene STARR-positive B cell enhancer ABC_E11495 Neighboring gene RUN domain containing 3A Neighboring gene STARR-positive B cell enhancer ABC_E5282 Neighboring gene microRNA 6930 Neighboring gene STARR-seq mESC enhancer starr_30808 Neighboring gene STARR-positive B cell enhancers ABC_E9375 and ABC_E8457 Neighboring gene granulin Neighboring gene family with sequence similarity 171, member A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Wang Y, et al. Nature, 2021 Nov. PMID 34707288, Free PMC Article
  2. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Nilsson R, et al. Cell Metab, 2009 Aug. PMID 19656490, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
    Title: SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
  2. Required for functional heme biosynthesis in erythroid cells. Possibly regulate ALAS2 through iron-sulfur cluster biogenesis.
    Title: Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC144572, MGC144573

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in glutathione import into mitochondrion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable mitochondrial glutathione transporter SLC25A39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026542.3 → NP_080818.1  probable mitochondrial glutathione transporter SLC25A39

    See identical proteins and their annotated locations for NP_080818.1

    Status: VALIDATED

    Source sequence(s)
    AK161289, BU758028, BY291748
    Consensus CDS
    CCDS25498.1
    UniProtKB/Swiss-Prot
    Q3TTM8, Q9D8K8
    UniProtKB/TrEMBL
    A2A697, Q14BQ5
    Related
    ENSMUSP00000018821.3, ENSMUST00000018821.9
    Conserved Domains (2) summary
    pfam00153
    Location:254 → 350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:71 → 94
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102293795..102299501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534035.1 → XP_006534098.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

    See identical proteins and their annotated locations for XP_006534098.1

    UniProtKB/Swiss-Prot
    Q3TTM8, Q9D8K8
    UniProtKB/TrEMBL
    A2A697, Q14BQ5
    Conserved Domains (2) summary
    pfam00153
    Location:254 → 350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:71 → 94
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

  2. XM_006534036.4 → XP_006534099.1  probable mitochondrial glutathione transporter SLC25A39 isoform X2

    UniProtKB/TrEMBL
    A2A697
    Related
    ENSMUSP00000115445.2, ENSMUST00000155104.8
    Conserved Domains (2) summary
    pfam00153
    Location:9 → 152
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:71 → 94
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

  3. XM_006534034.2 → XP_006534097.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

    See identical proteins and their annotated locations for XP_006534097.1

    UniProtKB/Swiss-Prot
    Q3TTM8, Q9D8K8
    UniProtKB/TrEMBL
    A2A697, Q14BQ5
    Conserved Domains (2) summary
    pfam00153
    Location:254 → 350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:71 → 94
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

  4. XM_030246255.1 → XP_030102115.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

    UniProtKB/Swiss-Prot
    Q3TTM8, Q9D8K8
    UniProtKB/TrEMBL
    A2A697, Q14BQ5
    Conserved Domains (2) summary
    pfam00153
    Location:254 → 350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:71 → 94
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

  5. XM_030246256.1 → XP_030102116.1  probable mitochondrial glutathione transporter SLC25A39 isoform X3

    Conserved Domains (1) summary
    pfam00153
    Location:153 → 249
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8K8.1 GenPept UniProtKB/Swiss-Prot:Q9D8K8

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