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Pdcd2l programmed cell death 2-like [ Mus musculus (house mouse) ]

Gene ID: 68079, updated on 5-Mar-2024

Summary

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Official Symbol
Pdcd2lprovided by MGI
Official Full Name
programmed cell death 2-likeprovided by MGI
Primary source
MGI:MGI:1915329
See related
Ensembl:ENSMUSG00000002635 AllianceGenome:MGI:1915329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030457N17Rik
Summary
Predicted to be located in cytoplasm. Orthologous to human PDCD2L (programmed cell death 2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 14.4), CNS E14 (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 19.45 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (33883922..33896154, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34184497..34196683, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like modifier activating enzyme 2 Neighboring gene STARR-seq mESC enhancer starr_18578 Neighboring gene STARR-seq mESC enhancer starr_18579 Neighboring gene STARR-seq mESC enhancer starr_18581 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10436 Neighboring gene glucose-6-phosphate isomerase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8163 Neighboring gene STARR-seq mESC enhancer starr_18586 Neighboring gene predicted gene 12762

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development. Houston BJ, et al. G3 (Bethesda), 2020 Dec 3. PMID 33055224, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development.
    Title: Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144595

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
programmed cell death protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360710.1 → NP_001347639.1  programmed cell death protein 2-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' end compared to variant 1, that cause a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BX537302
    UniProtKB/TrEMBL
    F6SGV3
    Related
    ENSMUSP00000115874.2, ENSMUST00000148381.3
    Conserved Domains (1) summary
    pfam04194
    Location:242 → 276
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

  2. NM_026549.4 → NP_080825.1  programmed cell death protein 2-like isoform 1

    See identical proteins and their annotated locations for NP_080825.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK151495, BX537302, CJ087550
    Consensus CDS
    CCDS21137.1
    UniProtKB/Swiss-Prot
    Q8C5N5, Q8R185, Q9D1M3
    Related
    ENSMUSP00000002710.4, ENSMUST00000002710.10
    Conserved Domains (1) summary
    pfam04194
    Location:242 → 356
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    33883922..33896154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153396.1 → XP_036009289.1  programmed cell death protein 2-like isoform X1

    UniProtKB/TrEMBL
    F6SGV3

RNA

  1. XR_003946551.2 RNA Sequence

  2. XR_004934177.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C5N5.1 GenPept UniProtKB/Swiss-Prot:Q8C5N5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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