Hsbp1 heat shock factor binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsbp1provided by MGI
Official Full Name: heat shock factor binding protein 1provided by MGI
Primary source: MGI:MGI:1915446
See related: Ensembl:ENSMUSG00000031839 AllianceGenome:MGI:1915446
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hsp25; 0610007A03Rik
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within endodermal cell differentiation. Predicted to be located in cytoskeleton. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including early embryo and ganglia. Orthologous to human HSBP1 (heat shock factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 226.9), CNS E18 (RPKM 192.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 67.54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (120071277..120075668)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (119344538..119348929)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSBP1 plays an essential role during early mouse and zebrafish embryonic development; lack of hsbp1 in embryoid bodies leads to disorganization of the germ layers and a reduction in the endoderm-specific markers.
Title: An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development.
In embryonic mandibles, chondrocytes in the anterior and intermediate portions of Meckel's cartilage showed Hsp25 immunoreactivity from the 12th day of gestation (E12) through E15.
Title: Different expression of 25-kDa heat-shock protein (Hsp25) in Meckel's cartilage compared with other cartilages in the mouse.
loss of z-disk and membrane scaffolding proteins immediately after lengthening contractions, and concomitant translocation of HSP25 and alphaB-crystallin to the z-disk, which may help to stabilize or repair cytoskeletal elements at this site.
Title: Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124761 (e-PCR)
- UniSTS:161583

RH127949 (e-PCR)
- UniSTS:211259

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonal transport of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in cellular heat acclimation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock factor-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.