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Wasl WASP like actin nucleation promoting factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 682507, updated on 25-Jan-2022

Summary

Official Symbol
Waslprovided by RGD
Official Full Name
WASP like actin nucleation promoting factorprovided by RGD
Primary source
RGD:735144
See related
Ensembl:ENSRNOG00000006975 AllianceGenome:RGD:735144
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TRS4; N-WASP
Summary
Enables cytoskeletal protein binding activity and identical protein binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of cellular component organization; and postsynaptic actin cytoskeleton organization. Located in Golgi membrane; cell leading edge; and cytoplasmic vesicle. Is active in glutamatergic synapse and postsynapse. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 186.2), Adrenal (RPKM 155.7) and 9 other tissues See more
Orthologs
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Genomic context

See Wasl in Genome Data Viewer
Location:
4q22
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (53083536..53132061, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (51677722..51726212, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350676 Neighboring gene ankyrin repeat and SOCS box containing 15 Neighboring gene leiomodin 2 Neighboring gene uncharacterized LOC120102244 Neighboring gene thymosin beta-10-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within cell projection assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane invagination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lymphocyte migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of membrane tubulation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of membrane tubulation ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in postsynaptic actin cytoskeleton organization EXP
Inferred from Experiment
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex localization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein-containing complex localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell projection assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in spindle localization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spindle localization ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle budding from membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle transport along actin filament IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cap IEA
Inferred from Electronic Annotation
more info
 
located_in actin cap ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
located_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
neural Wiskott-Aldrich syndrome protein
Names
Wiskott-Aldrich syndrome-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110365.1NP_001103835.1  neural Wiskott-Aldrich syndrome protein

    See identical proteins and their annotated locations for NP_001103835.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/TrEMBL
    F1LSG0
    Related
    ENSRNOP00000009261.6, ENSRNOT00000009261.7
    Conserved Domains (4) summary
    pfam00568
    Location:28135
    WH1; WH1 domain
    pfam00786
    Location:199256
    PBD; P21-Rho-binding domain
    cd22074
    Location:398424
    WH2_N-WASP_r1; first tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains
    cd22075
    Location:425449
    WH2_hN-WASP_r2_like; second tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    53083536..53132061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108349.1XP_038964277.1  neural Wiskott-Aldrich syndrome protein isoform X1

    Conserved Domains (4) summary
    pfam00568
    Location:28135
    WH1; WH1 domain
    pfam00786
    Location:199256
    PBD; P21-Rho-binding domain
    cd22074
    Location:404430
    WH2_N-WASP_r1; first tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains
    cd22075
    Location:431455
    WH2_hN-WASP_r2_like; second tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains
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