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Gstm7 glutathione S-transferase, mu 7 [ Mus musculus (house mouse) ]

Gene ID: 68312, updated on 5-Jan-2022

Summary

Official Symbol
Gstm7provided by MGI
Official Full Name
glutathione S-transferase, mu 7provided by MGI
Primary source
MGI:MGI:1915562
See related
Ensembl:ENSMUSG00000004035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd203c; AI894236; 0610005A07Rik
Summary
Predicted to enable several functions, including anion binding activity; glutathione peroxidase activity; and glutathione transferase activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; long-chain fatty acid metabolic process; and regulation of release of sequestered calcium ion into cytosol. Predicted to be located in cytosol; intercellular bridge; and sarcoplasmic reticulum. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Orthologous to human GSTM2 (glutathione S-transferase mu 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in genital fat pad adult (RPKM 289.7), liver adult (RPKM 39.7) and 8 other tissues See more
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Genomic context

See Gstm7 in Genome Data Viewer
Location:
3; 3 F2.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107833650..107839193, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107926334..107931877, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (107729252..107734663, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933431E20 gene Neighboring gene glutathione S-transferase, mu 5 Neighboring gene predicted gene 9515 Neighboring gene glutathione S-transferase, mu 6 Neighboring gene glutathione S-transferase, mu 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione S-transferase Mu 7
Names
GST class-mu 7
NP_001343280.1
NP_080948.2
XP_006502034.1
XP_006502036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356351.1NP_001343280.1  glutathione S-transferase Mu 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC079042, BC051924
    Consensus CDS
    CCDS89676.1
    Related
    ENSMUSP00000102299.2, ENSMUST00000106688.8
    Conserved Domains (2) summary
    cd03209
    Location:88208
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:980
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. NM_026672.3NP_080948.2  glutathione S-transferase Mu 7 isoform 1

    See identical proteins and their annotated locations for NP_080948.2

    Status: VALIDATED

    Source sequence(s)
    AI892118, BC051924
    Consensus CDS
    CCDS38595.1
    UniProtKB/Swiss-Prot
    Q80W21
    Related
    ENSMUSP00000004137.4, ENSMUST00000004137.11
    Conserved Domains (2) summary
    cd03209
    Location:92212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107833650..107839193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501971.4XP_006502034.1  glutathione S-transferase Mu 7 isoform X1

    Conserved Domains (2) summary
    cd03209
    Location:99219
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:2091
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. XM_006501973.4XP_006502036.1  glutathione S-transferase Mu 7 isoform X2

    Conserved Domains (2) summary
    cd03209
    Location:82202
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:374
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
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