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Crip2 cysteine rich protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68337, updated on 21-Apr-2024

Summary

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Official Symbol
Crip2provided by MGI
Official Full Name
cysteine rich protein 2provided by MGI
Primary source
MGI:MGI:1915587
See related
Ensembl:ENSMUSG00000006356 AllianceGenome:MGI:1915587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crp; Hlp; CRP2; CRP4; ESP1; 0610010I23Rik
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within hemopoiesis and positive regulation of cell population proliferation. Located in cell cortex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human CRIP2 (cysteine rich protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 931.2), lung adult (RPKM 531.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 61.57 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113103856..113109126)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113140236..113145506)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 Neighboring gene RIKEN cDNA F930026P19 gene Neighboring gene predicted gene, 30599 Neighboring gene cysteine-rich protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cyclic GMP-Dependent Regulation of Vascular Tone and Blood Pressure Involves Cysteine-Rich LIM-Only Protein 4 (CRP4). Längst N, et al. Int J Mol Sci, 2021 Sep 14. PMID 34576086, Free PMC Article
  2. Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain. Schmidtko A, et al. J Neurosci, 2008 Feb 6. PMID 18256252, Free PMC Article
  3. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. Karim MA, et al. Genomics, 1996 Jan 15. PMID 8824798
  4. Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts. Straubinger J, et al. FASEB J, 2017 Apr. PMID 28138039
  5. A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase. Zhang T, et al. J Biol Chem, 2007 Nov 16. PMID 17878170

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HOXA9 inhibits HIF1A-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.
    Title: HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.
  2. The persistence of Crip2 expression in cardiovascular tissues implies that Crip2 might exert an important impact on the cardiovascular development, maintenance and homeostasis.
    Title: Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions.
  3. role for the two LIM-domain gene Hlp in the very earliest stages of heart differentiation and development
    Title: The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family.
  4. observed characteristics of the LIM domain-containing adaptor protein CRIP2 are consistent with a potential role of PTP-BL in the dynamics of the cortical actin cytoskeleton
    Title: Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within hemopoiesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cysteine-rich protein 2
Names
CRP-2
LIM only protein HLP
heart LIM protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347443.1 → NP_001334372.1  cysteine-rich protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073562, AI851454, AK002484
    Consensus CDS
    CCDS84005.1
    UniProtKB/TrEMBL
    A0A0G2JF37
    Related
    ENSMUSP00000143334.2, ENSMUST00000200380.5
    Conserved Domains (1) summary
    cd09476
    Location:2 → 55
    LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

  2. NM_024223.2 → NP_077185.1  cysteine-rich protein 2 isoform 1

    See identical proteins and their annotated locations for NP_077185.1

    Status: VALIDATED

    Source sequence(s)
    AI851454, AK002484, CX217539
    Consensus CDS
    CCDS26204.1
    UniProtKB/Swiss-Prot
    Q9DCT8
    UniProtKB/TrEMBL
    Q4FJU3
    Related
    ENSMUSP00000081943.5, ENSMUST00000084882.9
    Conserved Domains (1) summary
    cd09476
    Location:5 → 58
    LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    113103856..113109126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246890.2 → XP_030102750.1  cysteine-rich protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JF37
    Related
    ENSMUSP00000143009.2, ENSMUST00000196015.5
    Conserved Domains (1) summary
    cd09476
    Location:2 → 55
    LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCT8.1 GenPept UniProtKB/Swiss-Prot:Q9DCT8

Gene LinkOut

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