Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mat2bprovided by RGD
Official Full Name: methionine adenosyltransferase 2 non-catalytic beta subunitprovided by RGD
Primary source: RGD:1593534
See related: Ensembl:ENSRNOG00000003177 AllianceGenome:RGD:1593534
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity and methionine adenosyltransferase regulator activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to be located in nucleus. Predicted to be part of methionine adenosyltransferase complex. Orthologous to human MAT2B (methionine adenosyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 338.7), Brain (RPKM 338.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (25609202..25626694, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (25106928..25122982, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (25832096..25848045, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups.
Title: Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups.
Investigated and confirmed protective effect of adipose-derived mesenchymal stem cells on miR-21-3p/methionine adenosyltransferase 2B (MAT2B) signal transduction in a rat ischemic brain injury model.
Title: Adipose-derived mesenchymal stem cells attenuate ischemic brain injuries in rats by modulating miR-21-3p/MAT2B signaling transduction.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU022853 (e-PCR)
- UniSTS:208659

RH134368 (e-PCR)
- UniSTS:217650

RH143265 (e-PCR)
- UniSTS:232512

AI182287 (e-PCR)
- UniSTS:160083

RH137200 (e-PCR)
- UniSTS:219288

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables methionine adenosyltransferase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase regulator activity	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase regulator activity	ISO Inferred from Sequence Orthology more info
enables methionine adenosyltransferase regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in S-adenosylmethionine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in S-adenosylmethionine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of methionine adenosyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of methionine adenosyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of methionine adenosyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of methionine adenosyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: methionine adenosyltransferase 2 subunit beta

Names: MAT II beta; methionine adenosyltransferase 2 beta subunit; methionine adenosyltransferase 2B; methionine adenosyltransferase II, beta

NP_001037747.1

EC 2.5.1.6

XP_006246188.1

EC 2.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044282.1 → NP_001037747.1 methionine adenosyltransferase 2 subunit beta

See identical proteins and their annotated locations for NP_001037747.1

Status: PROVISIONAL

Source sequence(s)

BC085899

UniProtKB/Swiss-Prot

Q5U2R0

UniProtKB/TrEMBL

A0A8L2Q226, A6HDK5

Related

ENSRNOP00000004269.6, ENSRNOT00000004269.7

Conserved Domains (1) summary

cd05254
Location:30 → 316

dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

25609202..25626694 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246126.5 → XP_006246188.1 methionine adenosyltransferase 2 subunit beta isoform X1

See identical proteins and their annotated locations for XP_006246188.1

UniProtKB/TrEMBL

A0A0G2JT30, A0A8I5ZYI5, A6HDK4

Related

ENSRNOP00000084010.1

Conserved Domains (1) summary

cd05254
Location:19 → 305

dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs