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Nat8 N-acetyltransferase 8 (GCN5-related) [ Mus musculus (house mouse) ]

Gene ID: 68396, updated on 8-Feb-2024

Summary

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Official Symbol
Nat8provided by MGI
Official Full Name
N-acetyltransferase 8 (GCN5-related)provided by MGI
Primary source
MGI:MGI:1915646
See related
Ensembl:ENSMUSG00000030004 AllianceGenome:MGI:1915646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cml4; CCNAT; ATase2; 0610037O16Rik
Summary
Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Involved in gastrulation with mouth forming second. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be integral component of membrane. Orthologous to several human genes including NAT8 (N-acetyltransferase 8 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 43.2), duodenum adult (RPKM 18.8) and 4 other tissues See more
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Genomic context

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Location:
6 C3; 6 37.49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85807369..85813839, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85830387..85836857, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 6 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 5 Neighboring gene prostaglandin E synthase 3, pseudogene Neighboring gene STARR-seq mESC enhancer starr_16509 Neighboring gene predicted gene, 38847

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism. Rigby MJ, et al. Commun Biol, 2021 Apr 12. PMID 33846551, Free PMC Article
  2. The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats. Fu J, et al. PLoS One, 2014. PMID 25057902, Free PMC Article
  3. DUX is a non-essential synchronizer of zygotic genome activation. De Iaco A, et al. Development, 2020 Jan 23. PMID 31806660, Free PMC Article
  4. Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. Popsueva AE, et al. Dev Biol, 2001 Jun 15. PMID 11397015
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that Nat8 is down-regulated in liver ischemia/reperfusion injury and its upregulation prevents it suggesting its protective effect against liver injuries.
    Title: The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyltransferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-S-conjugate N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell adhesion ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in endoplasmic reticulum ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in late recombination nodule ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
N-acetyltransferase 8
Names
N-acetyltransferase 8 (GCN5-related, putative)
acetyltransferase 2
camello-like 4
camello-like protein 4
cysteinyl-conjugate N-acetyltransferase
probable N-acetyltransferase CML4
NP_001348989.1
NP_075944.1
XP_006506599.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362060.1 → NP_001348989.1  N-acetyltransferase 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161888
    Consensus CDS
    CCDS20301.1
    UniProtKB/Swiss-Prot
    Q9JIY7
    Conserved Domains (1) summary
    pfam00583
    Location:91 → 193
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. NM_023455.4 → NP_075944.1  N-acetyltransferase 8

    See identical proteins and their annotated locations for NP_075944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant (1). Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161888
    Consensus CDS
    CCDS20301.1
    UniProtKB/Swiss-Prot
    Q9JIY7
    Related
    ENSMUSP00000032073.7, ENSMUST00000032073.7
    Conserved Domains (1) summary
    pfam00583
    Location:91 → 193
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85807369..85813839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506536.3 → XP_006506599.1  N-acetyltransferase 8 isoform X1

    See identical proteins and their annotated locations for XP_006506599.1

    UniProtKB/Swiss-Prot
    Q9JIY7
    Conserved Domains (1) summary
    pfam00583
    Location:91 → 193
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIY7.1 GenPept UniProtKB/Swiss-Prot:Q9JIY7

Gene LinkOut

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