Dhrs7c dehydrogenase/reductase 7C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dhrs7cprovided by MGI
Official Full Name: dehydrogenase/reductase 7Cprovided by MGI
Primary source: MGI:MGI:1915710
See related: Ensembl:ENSMUSG00000033044 AllianceGenome:MGI:1915710
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SRP-35; 1110001P11Rik
Summary: Enables NAD-retinol dehydrogenase activity. Acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Located in longitudinal sarcoplasmic reticulum and sarcoplasmic reticulum membrane. Orthologous to human DHRS7C (dehydrogenase/reductase 7C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 73.2) and mammary gland adult (RPKM 9.8) See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 41.13 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (67689097..67706828)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (67798271..67816002)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrates that the skeletal muscle protein SRP-35, a retinol dehydrogenase, is directly involved in skeletal muscle metabolism, since its over-expression results in higher glucose uptake and increased glycogen storage. In addition, SRP-35 over-expression improves muscle performance in vivo.
Title: Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance.
Taken together, our findings suggested that DHRS7C maintains intracellular Ca(2+) homeostasis involving the ER/SR and that functional loss of DHRS7C leads to Ca(2+) overload in the cytosol and ER/SR, resulting in enlarged cellular morphology via calpain activation
Title: Functional loss of DHRS7C induces intracellular Ca2+ overload and myotube enlargement in C2C12 cells via calpain activation.
skeletal muscle SRP-35 is involved in the generation of all-trans-retinaldehyde and may play an important role in the generation of intracellular signals linking Ca2+ release (i.e. muscle activity) to metabolism.
Title: SRP-35, a newly identified protein of the skeletal muscle sarcoplasmic reticulum, is a retinol dehydrogenase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in glucose import	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in longitudinal sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member 7C

Names: dehydrogenase/reductase (SDR family) member 7C; sarcoplasmic reticulum protein of 35 kDa; short-chain dehydrogenase/reductase family 32C member 2

NP_001013031.2

EC 1.1.1.105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013013.2 → NP_001013031.2 dehydrogenase/reductase SDR family member 7C precursor

See identical proteins and their annotated locations for NP_001013031.2

Status: VALIDATED

Source sequence(s)

AA063835, AI391290, AI414355, CJ048402, W53606

Consensus CDS

CCDS48822.1

UniProtKB/Swiss-Prot

B1ATJ2, Q8CHS7

Related

ENSMUSP00000130924.2, ENSMUST00000168612.8

Conserved Domains (2) summary

cd05332
Location:35 → 296

11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

PRK06181
Location:37 → 293

PRK06181; short chain dehydrogenase; Provisional