U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp385a zinc finger protein 385A [ Rattus norvegicus (Norway rat) ]

Gene ID: 685474, updated on 30-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp385aprovided by RGD
Official Full Name
zinc finger protein 385Aprovided by RGD
Primary source
RGD:1593784
See related
Ensembl:ENSRNOG00000036833 AllianceGenome:RGD:1593784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfp385
Summary
Predicted to enable mRNA 3'-UTR binding activity and p53 binding activity. Predicted to be involved in several processes, including cellular response to DNA damage stimulus; posttranscriptional regulation of gene expression; and regulation of signal transduction by p53 class mediator. Predicted to act upstream of or within several processes, including myeloid cell differentiation; platelet alpha granule organization; and positive regulation of fat cell differentiation. Predicted to be located in dendrite. Predicted to be active in neuronal cell body and nucleus. Predicted to colocalize with chromatin. Orthologous to human ZNF385A (zinc finger protein 385A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 25.3), Brain (RPKM 22.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136327393..136354017, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134448914..134475548, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144939616..144966364, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene microRNA 148b Neighboring gene G protein-coupled receptor 84 Neighboring gene uncharacterized LOC134479585 Neighboring gene integrin subunit alpha 5 Neighboring gene gametocyte specific factor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Impaired motor functions in mice lacking the RNA-binding protein Hzf. Iijima T, et al. Neurosci Res, 2007 Jun. PMID 17383763
  2. Hzf regulates adipogenesis through translational control of C/EBPalpha. Kawagishi H, et al. EMBO J, 2008 May 21. PMID 18418387, Free PMC Article
  3. Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. Kimura Y, et al. J Exp Med, 2002 Apr 1. PMID 11927637, Free PMC Article
  4. Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA. Iijima T, et al. Proc Natl Acad Sci U S A, 2005 Nov 22. PMID 16286649, Free PMC Article
  5. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Das S, et al. Cell, 2007 Aug 24. PMID 17719541, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within hemostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular mRNA localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within learning or memory ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA localization resulting in post-transcriptional regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA localization resulting in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within megakaryocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet alpha granule organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 385A
Names
zinc finger protein 385

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109470.2 → NP_001102940.1  zinc finger protein 385A isoform 2

    See identical proteins and their annotated locations for NP_001102940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K3Y0, A0A0G2KB91, A6KD07
    Related
    ENSRNOP00000075700.1, ENSRNOT00000083935.2
    Conserved Domains (2) summary
    sd00020
    Location:203 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:261 → 285
    zf-met; Zinc-finger of C2H2 type

  2. NM_001135088.1 → NP_001128560.1  zinc finger protein 385A isoform 1

    See identical proteins and their annotated locations for NP_001128560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC166729
    UniProtKB/TrEMBL
    A0A0G2K3Y0, B2RYC6, F7FKR3
    Related
    ENSRNOP00000059042.3, ENSRNOT00000064261.3
    Conserved Domains (2) summary
    sd00020
    Location:232 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:291 → 314
    zf-met; Zinc-finger of C2H2 type

  3. NM_001135089.1 → NP_001128561.1  zinc finger protein 385A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K3Y0
    Conserved Domains (2) summary
    sd00020
    Location:183 → 205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:241 → 265
    zf-met; Zinc-finger of C2H2 type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    136327393..136354017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079900.2 → XP_038935828.1  zinc finger protein 385A isoform X2

    UniProtKB/TrEMBL
    A0A0G2K3Y0
    Related
    ENSRNOP00000072821.2
    Conserved Domains (2) summary
    sd00020
    Location:219 → 241
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:277 → 301
    zf-met; Zinc-finger of C2H2 type

  2. XM_063264261.1 → XP_063120331.1  zinc finger protein 385A isoform X3

  3. XM_039079899.2 → XP_038935827.1  zinc finger protein 385A isoform X1

    UniProtKB/TrEMBL
    A0A0G2K3Y0
    Conserved Domains (2) summary
    sd00020
    Location:240 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:298 → 322
    zf-met; Zinc-finger of C2H2 type

  4. XM_039079901.2 → XP_038935829.1  zinc finger protein 385A isoform X4

    UniProtKB/TrEMBL
    A0A0G2K3Y0, A0A8I6AE41
    Related
    ENSRNOP00000091668.1
    Conserved Domains (2) summary
    sd00020
    Location:164 → 186
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:222 → 246
    zf-met; Zinc-finger of C2H2 type
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous