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Cgref1 cell growth regulator with EF hand domain 1 [ Mus musculus (house mouse) ]

Gene ID: 68567, updated on 5-Mar-2024

Summary

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Official Symbol
Cgref1provided by MGI
Official Full Name
cell growth regulator with EF hand domain 1provided by MGI
Primary source
MGI:MGI:1915817
See related
Ensembl:ENSMUSG00000029161 AllianceGenome:MGI:1915817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cgr11; 1110004G24Rik
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of cell growth. Predicted to act upstream of or within cell adhesion and regulation of cell cycle. Predicted to be located in extracellular region. Is expressed in several structures, including bone; forelimb; heart ventricle; nervous system; and urinary system. Orthologous to human CGREF1 (cell growth regulator with EF-hand domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 402.2), kidney adult (RPKM 154.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Cgref1 in Genome Data Viewer
Location:
5 B1; 5 16.9 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31090487..31102771, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30933143..30945480, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31218364-31218473 Neighboring gene elastin microfibril interfacer 1 Neighboring gene STARR-positive B cell enhancer ABC_E4749 Neighboring gene ketohexokinase Neighboring gene STARR-positive B cell enhancer ABC_E1679 Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding Neighboring gene transcription factor 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cgr11 encodes a secretory protein involved in cell adhesion. Devnath S, et al. Eur J Cell Biol, 2009 Sep. PMID 19473726
  2. Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Inoue SI, et al. Hum Mol Genet, 2017 Dec 1. PMID 28973166
  3. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  4. Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model. Hecht J, et al. Gene Expr Patterns, 2007 Jan. PMID 16829211
  5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell growth regulator with EF hand domain protein 1
Names
cell growth regulatory gene 11 protein
cell growth regulatory with EF-hand domain
hydrophobestin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160149.1 → NP_001153621.1  cell growth regulator with EF hand domain protein 1 precursor

    See identical proteins and their annotated locations for NP_001153621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK003420, BQ043218, CB202031
    UniProtKB/Swiss-Prot
    Q8R1U2, Q9D1K1
    UniProtKB/TrEMBL
    E9QPK1
    Conserved Domains (2) summary
    TIGR00927
    Location:184 → 278
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam13499
    Location:73 → 143
    EF-hand_7; EF-hand domain pair

  2. NM_026770.2 → NP_081046.2  cell growth regulator with EF hand domain protein 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC109606
    Consensus CDS
    CCDS51454.1
    UniProtKB/Swiss-Prot
    Q8R1U2, Q9D1K1
    UniProtKB/TrEMBL
    E9QPK1
    Related
    ENSMUSP00000031051.8, ENSMUST00000031051.9
    Conserved Domains (2) summary
    TIGR00927
    Location:184 → 278
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam13499
    Location:73 → 143
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31090487..31102771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1U2.1 GenPept UniProtKB/Swiss-Prot:Q8R1U2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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