U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Letmd1 LETM1 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 68614, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Letmd1provided by MGI
Official Full Name
LETM1 domain containing 1provided by MGI
Primary source
MGI:MGI:1915864
See related
Ensembl:ENSMUSG00000037353 AllianceGenome:MGI:1915864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mccr; HCCR1; HCCR-2; MCC-32; 1110019O13Rik
Summary
Predicted to enable ribosome binding activity. Located in mitochondrion. Is expressed in several structures, including brain; cranial ganglion; dorsal root ganglion; and retina. Orthologous to human LETMD1 (LETM1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 33.3), mammary gland adult (RPKM 24.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Letmd1 in Genome Data Viewer
Location:
15 F1; 15 56.31 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100360302..100377133)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100462421..100479252)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene methyltransferase hypoxia inducible domain containing 1 Neighboring gene HIG1 domain family, member 1C Neighboring gene predicted gene, 53911 Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E4149 Neighboring gene RIKEN cDNA 5330439K02 gene Neighboring gene predicted gene 5475 Neighboring gene STARR-positive B cell enhancer mm9_chr15:100274003-100274304 Neighboring gene STARR-seq mESC enhancer starr_39750 Neighboring gene STARR-seq mESC enhancer starr_39751 Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene STARR-seq mESC enhancer starr_39756 Neighboring gene transcription factor CP2 Neighboring gene STARR-positive B cell enhancer ABC_E7419 Neighboring gene STARR-seq mESC enhancer starr_39757 Neighboring gene STARR-positive B cell enhancer ABC_E4150

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice. Park A, et al. Nat Commun, 2023 Jun 23. PMID 37353518, Free PMC Article
  2. Deletion of Letmd1 leads to the disruption of mitochondrial function in brown adipose tissue. Song R, et al. Biochimie, 2022 Oct. PMID 35817133
  3. LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes. Snyder MM, et al. FASEB J, 2021 Nov. PMID 34669999
  4. Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Xiao H, et al. Cell, 2022 Nov 23. PMID 36334589, Free PMC Article
  5. LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages. Lim SG, et al. J Immunol, 2020 Mar 1. PMID 31980577

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.
    Title: LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.
  2. Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice.
    Title: Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice.
  3. Deletion of Letmd1 leads to the disruption of mitochondrial function in brown adipose tissue.
    Title: Deletion of Letmd1 leads to the disruption of mitochondrial function in brown adipose tissue.
  4. Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1.
    Title: Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1.
  5. LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes.
    Title: LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes.
  6. LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-kappaB Activation in Macrophages.
    Title: LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages.
  7. HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE
    Title: Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and its implication for breast cancer and obesity.
  8. The level of HCCR-1 expression was increased during the mouse embryogenesis and expression of phosphatidylinositol 3-kinase (PI3K) in NIH/3T3 cells activated the HCCR-1 promoter.
    Title: The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
LETM1 domain-containing protein 1
Names
cervical cancer receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357982.1 → NP_001344911.1  LETM1 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC139571
    Consensus CDS
    CCDS88845.1
    Related
    ENSMUSP00000155807.2, ENSMUST00000230294.2
    Conserved Domains (1) summary
    pfam07766
    Location:1 → 188
    LETM1; LETM1-like protein

  2. NM_001357983.1 → NP_001344912.1  LETM1 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC139571
    Conserved Domains (1) summary
    pfam07766
    Location:1 → 254
    LETM1; LETM1-like protein

  3. NM_001357984.1 → NP_001344913.1  LETM1 domain-containing protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC139571
    Consensus CDS
    CCDS88844.1
    Related
    ENSMUSP00000155084.2, ENSMUST00000229648.2
    Conserved Domains (1) summary
    pfam07766
    Location:1 → 256
    LETM1; LETM1-like protein

  4. NM_134093.3 → NP_598854.1  LETM1 domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_598854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC139571
    Consensus CDS
    CCDS27838.1
    UniProtKB/Swiss-Prot
    Q3TF05, Q3U3M7, Q8BLG9, Q8K1F7, Q8VDS9, Q924L1
    Related
    ENSMUSP00000037546.9, ENSMUST00000037001.10
    Conserved Domains (1) summary
    pfam07766
    Location:80 → 338
    LETM1; LETM1-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100360302..100377133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316739.2 → XP_017172228.1  LETM1 domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q924L1
    Conserved Domains (1) summary
    pfam07766
    Location:1 → 188
    LETM1; LETM1-like protein

  2. XM_006521322.3 → XP_006521385.1  LETM1 domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006521385.1

    UniProtKB/Swiss-Prot
    Q924L1
    Conserved Domains (1) summary
    pfam07766
    Location:1 → 188
    LETM1; LETM1-like protein

  3. XM_036159561.1 → XP_036015454.1  LETM1 domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    pfam07766
    Location:1 → 186
    LETM1; LETM1-like protein

  4. XM_036159562.1 → XP_036015455.1  LETM1 domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    pfam07766
    Location:1 → 186
    LETM1; LETM1-like protein

  5. XM_030248726.2 → XP_030104586.1  LETM1 domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    pfam07766
    Location:116 → 244
    LETM1; LETM1-like protein

  6. XM_006521320.4 → XP_006521383.1  LETM1 domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam07766
    Location:79 → 343
    LETM1; LETM1-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924L1.1 GenPept UniProtKB/Swiss-Prot:Q924L1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous