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Mtcl1 microtubule crosslinking factor 1 [ Mus musculus (house mouse) ]

Gene ID: 68617, updated on 11-Apr-2024

Summary

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Official Symbol
Mtcl1provided by MGI
Official Full Name
microtubule crosslinking factor 1provided by MGI
Primary source
MGI:MGI:1915867
See related
Ensembl:ENSMUSG00000052105 AllianceGenome:MGI:1915867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Soga2; Ccdc165; Kiaa0802; t8219b25; mKIAA0802; D130071O13; 1110012J17Rik
Summary
Enables microtubule binding activity and protein homodimerization activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity; microtubule bundle formation; and positive regulation of protein targeting to membrane. Located in several cellular components, including apicolateral plasma membrane; cytoskeleton; and lateral plasma membrane. Is expressed in several structures, including alimentary system; cranial ganglion; limb segment; metanephros; and neural ectoderm. Orthologous to human MTCL1 (microtubule crosslinking factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 17.8), lung adult (RPKM 10.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E1.1; 17 35.3 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66643975..66760672, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (66336980..66449806, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20742 Neighboring gene STARR-seq mESC enhancer starr_43046 Neighboring gene STARR-seq mESC enhancer starr_43047 Neighboring gene periphilin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43048 Neighboring gene STARR-seq mESC enhancer starr_43049 Neighboring gene STARR-seq mESC enhancer starr_43051 Neighboring gene STARR-seq mESC enhancer starr_43052 Neighboring gene STARR-seq mESC enhancer starr_43061 Neighboring gene STARR-seq mESC enhancer starr_43062 Neighboring gene predicted gene 4705 Neighboring gene STARR-seq mESC enhancer starr_43065 Neighboring gene STARR-seq mESC enhancer starr_43067 Neighboring gene STARR-seq mESC enhancer starr_43070 Neighboring gene VISTA enhancer mm1499 Neighboring gene STARR-seq mESC enhancer starr_43072 Neighboring gene RAB12, member RAS oncogene family Neighboring gene predicted gene, 41608 Neighboring gene STARR-seq mESC enhancer starr_43077 Neighboring gene STARR-seq mESC enhancer starr_43079 Neighboring gene thymocyte selection associated family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MTCL1 plays an essential role in maintaining Purkinje neuron axon initial segment. Satake T, et al. EMBO J, 2017 May 2. PMID 28283581, Free PMC Article
  2. The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells. Sato Y, et al. J Cell Sci, 2013 Oct 15. PMID 23902687
  3. FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Araujo DJ, et al. Genes Dev, 2015 Oct 15. PMID 26494785, Free PMC Article
  4. Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Sousa-Nunes R, et al. Genome Res, 2003 Dec. PMID 14613977, Free PMC Article
  5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC77963

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of epithelial cell apical/basal polarity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule bundle formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apicolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
is_active_in lateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule bundle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule bundle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microtubule cross-linking factor 1
Names
PAR-1-interacting protein
SOGA family member 2
coiled-coil domain-containing protein 165
protein SOGA2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114098.2 → NP_001107570.1  microtubule cross-linking factor 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    CT010496, CT025601
    Consensus CDS
    CCDS50168.1
    UniProtKB/TrEMBL
    H3BL83
    Related
    ENSMUSP00000094894.4, ENSMUST00000097291.10
    Conserved Domains (5) summary
    pfam00261
    Location:338 → 543
    Tropomyosin; Tropomyosin
    pfam10812
    Location:123 → 182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:622 → 714
    DUF3166; Protein of unknown function (DUF3166)
    pfam13863
    Location:432 → 533
    DUF4200; Domain of unknown function (DUF4200)
    pfam14818
    Location:1220 → 1341
    DUF4482; Domain of unknown function (DUF4482)

  2. NM_172963.4 → NP_766551.3  microtubule cross-linking factor 1 isoform 2

    See identical proteins and their annotated locations for NP_766551.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' region, which results in a downstream translation termination codon, compared to variant 1. The resulting isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK147205, BP760436
    Consensus CDS
    CCDS28946.2
    UniProtKB/Swiss-Prot
    Q3UHU5, Q6PAM2, Q80TR7
    Related
    ENSMUSP00000083899.6, ENSMUST00000086693.12
    Conserved Domains (5) summary
    pfam00261
    Location:338 → 543
    Tropomyosin; Tropomyosin
    pfam10812
    Location:123 → 182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:622 → 714
    DUF3166; Protein of unknown function (DUF3166)
    pfam13863
    Location:432 → 533
    DUF4200; Domain of unknown function (DUF4200)
    pfam14818
    Location:1220 → 1341
    DUF4482; Domain of unknown function (DUF4482)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    66643975..66760672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524849.4 → XP_006524912.1  microtubule cross-linking factor 1 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:13 → 317
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:337 → 693
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11365
    Location:658 → 750
    SOGA; Protein SOGA
    pfam14818
    Location:1297 → 1418
    DUF4482; Domain of unknown function (DUF4482)

  2. XM_011246587.4 → XP_011244889.1  microtubule cross-linking factor 1 isoform X7

    UniProtKB/TrEMBL
    H3BL83
    Related
    ENSMUSP00000135690.2, ENSMUST00000177034.2
    Conserved Domains (5) summary
    PHA03247
    Location:13 → 317
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:340 → 648
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02463
    Location:330 → 1103
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam11365
    Location:622 → 714
    SOGA; Protein SOGA
    pfam14818
    Location:1261 → 1382
    DUF4482; Domain of unknown function (DUF4482)

  3. XM_036160766.1 → XP_036016659.1  microtubule cross-linking factor 1 isoform X6

    Conserved Domains (5) summary
    PHA03247
    Location:13 → 317
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:340 → 659
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:367 → 1277
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11365
    Location:633 → 725
    SOGA; Protein SOGA
    pfam14818
    Location:1231 → 1352
    DUF4482; Domain of unknown function (DUF4482)

  4. XM_006524853.5 → XP_006524916.1  microtubule cross-linking factor 1 isoform X4

    Conserved Domains (4) summary
    PHA03247
    Location:13 → 317
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:337 → 693
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11365
    Location:658 → 750
    SOGA; Protein SOGA
    pfam14818
    Location:1256 → 1377
    DUF4482; Domain of unknown function (DUF4482)

  5. XM_017317622.3 → XP_017173111.1  microtubule cross-linking factor 1 isoform X8

    Conserved Domains (4) summary
    PHA03247
    Location:13 → 317
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:337 → 693
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11365
    Location:658 → 750
    SOGA; Protein SOGA
    pfam14818
    Location:1256 → 1377
    DUF4482; Domain of unknown function (DUF4482)

  6. XM_006524856.4 → XP_006524919.1  microtubule cross-linking factor 1 isoform X5

    UniProtKB/TrEMBL
    H3BL83
    Conserved Domains (4) summary
    PHA03247
    Location:13 → 317
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:337 → 693
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam11365
    Location:658 → 750
    SOGA; Protein SOGA
    pfam14818
    Location:1297 → 1418
    DUF4482; Domain of unknown function (DUF4482)

  7. XM_036160768.1 → XP_036016661.1  microtubule cross-linking factor 1 isoform X9

    Conserved Domains (3) summary
    PHA03247
    Location:13 → 317
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:338 → 780
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam14818
    Location:731 → 852
    DUF4482; Domain of unknown function (DUF4482)

  8. XM_006524852.5 → XP_006524915.1  microtubule cross-linking factor 1 isoform X3

    Conserved Domains (5) summary
    PHA03247
    Location:13 → 317
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:340 → 648
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02463
    Location:330 → 1103
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam11365
    Location:622 → 714
    SOGA; Protein SOGA
    pfam14818
    Location:1261 → 1382
    DUF4482; Domain of unknown function (DUF4482)

  9. XM_006524851.5 → XP_006524914.1  microtubule cross-linking factor 1 isoform X2

    Conserved Domains (5) summary
    PHA03247
    Location:13 → 317
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:340 → 659
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02463
    Location:330 → 1114
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam11365
    Location:633 → 725
    SOGA; Protein SOGA
    pfam14818
    Location:1272 → 1393
    DUF4482; Domain of unknown function (DUF4482)

RNA

  1. XR_001782108.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHU5.1 GenPept UniProtKB/Swiss-Prot:Q3UHU5

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