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Cryl1 crystallin, lambda 1 [ Mus musculus (house mouse) ]

Gene ID: 68631, updated on 5-Mar-2024

Summary

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Official Symbol
Cryl1provided by MGI
Official Full Name
crystallin, lambda 1provided by MGI
Primary source
MGI:MGI:1915881
See related
Ensembl:ENSMUSG00000021947 AllianceGenome:MGI:1915881
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gul3dh; 1110025H08Rik; A230106J09Rik
Summary
Predicted to enable L-gulonate 3-dehydrogenase activity; NAD+ binding activity; and protein homodimerization activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; hemolymphoid system; metanephros; nose; and secondary oocyte. Orthologous to human CRYL1 (crystallin lambda 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 161.7), duodenum adult (RPKM 56.6) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Cryl1 in Genome Data Viewer
Location:
14 C3; 14 30.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (57512491..57635940, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57275034..57398483, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene gap junction protein, beta 6 Neighboring gene predicted gene 8996 Neighboring gene predicted gene, 23593 Neighboring gene predicted gene 8971 Neighboring gene STARR-positive B cell enhancer ABC_E1897 Neighboring gene predicted gene, 41161 Neighboring gene predicted gene, 29717 Neighboring gene STARR-seq mESC enhancer starr_36807 Neighboring gene intraflagellar transport 88 Neighboring gene STARR-positive B cell enhancer ABC_E5444 Neighboring gene STARR-positive B cell enhancer mm9_chr14:58144327-58144627 Neighboring gene STARR-seq mESC enhancer starr_36808 Neighboring gene interleukin 17D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. Ishikura S, et al. J Biochem, 2005 Mar. PMID 15809331
  2. Studies on dehydrogenases of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Tulsiani DR, et al. Diabetes, 1979 Sep. PMID 38160
  3. Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians. Chen J, et al. Gene, 2003 Jan 2. PMID 12527201
  4. Identification of candidate maternal-effect genes through comparison of multiple microarray data sets. Mager J, et al. Mamm Genome, 2006 Sep. PMID 16964442
  5. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, et al. Genomics, 2004 Nov. PMID 15475267

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-gulonate 3-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-gulonate 3-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucuronate catabolic process to xylulose 5-phosphate IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lambda-crystallin homolog
Names
L-gulonate 3-dehydrogenase
crystallin, lamda 1
NP_084280.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030004.3 → NP_084280.2  lambda-crystallin homolog

    See identical proteins and their annotated locations for NP_084280.2

    Status: PROVISIONAL

    Source sequence(s)
    CT010506
    Consensus CDS
    CCDS27155.1
    UniProtKB/Swiss-Prot
    Q542R9, Q8R4W7, Q99KP3
    UniProtKB/TrEMBL
    A7VMV2
    Related
    ENSMUSP00000022517.8, ENSMUST00000022517.9
    Conserved Domains (3) summary
    PRK06129
    Location:9 → 313
    PRK06129; 3-hydroxyacyl-CoA dehydrogenase; Validated
    pfam00725
    Location:192 → 259
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:9 → 186
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    57512491..57635940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KP3.3 GenPept UniProtKB/Swiss-Prot:Q99KP3

Gene LinkOut

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