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Kansl1l KAT8 regulatory NSL complex subunit 1-like [ Mus musculus (house mouse) ]

Gene ID: 68691, updated on 5-Mar-2024

Summary

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Official Symbol
Kansl1lprovided by MGI
Official Full Name
KAT8 regulatory NSL complex subunit 1-likeprovided by MGI
Primary source
MGI:MGI:1915941
See related
Ensembl:ENSMUSG00000026004 AllianceGenome:MGI:1915941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4189; 1190030G24; 1110028C15Rik; C430010P07Rik
Summary
Predicted to enable histone acetyltransferase binding activity. Predicted to be part of NSL complex. Orthologous to human KANSL1L (KAT8 regulatory NSL complex subunit 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 1.9), bladder adult (RPKM 1.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Kansl1l in Genome Data Viewer
Location:
1 C3; 1 33.61 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66758402..66856754, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66719243..66817596, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 2 Neighboring gene predicted gene, 25411 Neighboring gene STARR-seq mESC enhancer starr_01189 Neighboring gene unc-80, NALCN activator Neighboring gene predicted gene, 39655 Neighboring gene STARR-seq mESC enhancer starr_01190 Neighboring gene STARR-seq mESC enhancer starr_01191 Neighboring gene STARR-positive B cell enhancer ABC_E5767 Neighboring gene ribulose-5-phosphate-3-epimerase Neighboring gene STARR-positive B cell enhancer ABC_E11073 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:66862655-66862957 Neighboring gene STARR-positive B cell enhancer ABC_E4319 Neighboring gene predicted gene, 46093 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5768 Neighboring gene predicted gene 15793 Neighboring gene predicted gene, 27934 Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • KIAA4189, MGC175997, AC118589.2

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone acetyltransferase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
KAT8 regulatory NSL complex subunit 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122738.1 → NP_001116210.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK082897, AK138707, AK145440, BB793048, CJ177470
    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:764 → 884
    PEHE; PEHE domain

  2. NM_001357156.1 → NP_001344085.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC118589, AC124389
    Consensus CDS
    CCDS35603.1
    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:755 → 875
    PEHE; PEHE domain

  3. NM_001357157.1 → NP_001344086.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC118589, AC124389
    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:754 → 845
    PEHE; PEHE domain

  4. NM_001368830.1 → NP_001355759.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC118589, AC124389
    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:720 → 811
    PEHE; PEHE domain

  5. NM_177645.4 → NP_808313.3  KAT8 regulatory NSL complex subunit 1-like protein isoform 2

    See identical proteins and their annotated locations for NP_808313.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK082897, AK138707, AK145440, AK220534, BB793048, CJ177470
    Consensus CDS
    CCDS35603.1
    UniProtKB/TrEMBL
    B2RUA4
    Related
    ENSMUSP00000063843.4, ENSMUST00000068168.10
    Conserved Domains (1) summary
    pfam15275
    Location:755 → 875
    PEHE; PEHE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    66758402..66856754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322317.2 → XP_017177806.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X12

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:754 → 845
    PEHE; PEHE domain

  2. XM_017322311.2 → XP_017177800.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X5

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:798 → 889
    PEHE; PEHE domain

  3. XM_006496241.3 → XP_006496304.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X3

    See identical proteins and their annotated locations for XP_006496304.1

    UniProtKB/Swiss-Prot
    B2KGC3, E9QLD1, Q3TC00, Q5DTI6, Q8BNM1, Q8C4R5
    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:799 → 919
    PEHE; PEHE domain

  4. XM_030242671.2 → XP_030098531.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X13

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:720 → 811
    PEHE; PEHE domain

  5. XM_030242649.2 → XP_030098509.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X3

    UniProtKB/Swiss-Prot
    B2KGC3, E9QLD1, Q3TC00, Q5DTI6, Q8BNM1, Q8C4R5
    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:799 → 919
    PEHE; PEHE domain

  6. XM_030242665.2 → XP_030098525.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X9

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:763 → 883
    PEHE; PEHE domain

  7. XM_036153352.1 → XP_036009245.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X8

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:764 → 884
    PEHE; PEHE domain

  8. XM_011238574.3 → XP_011236876.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

    See identical proteins and their annotated locations for XP_011236876.1

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:834 → 954
    PEHE; PEHE domain

  9. XM_036153358.1 → XP_036009251.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X10

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:755 → 875
    PEHE; PEHE domain

  10. XM_036153341.1 → XP_036009234.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X3

    UniProtKB/Swiss-Prot
    B2KGC3, E9QLD1, Q3TC00, Q5DTI6, Q8BNM1, Q8C4R5
    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:799 → 919
    PEHE; PEHE domain

  11. XM_011238571.3 → XP_011236873.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

    See identical proteins and their annotated locations for XP_011236873.1

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:834 → 954
    PEHE; PEHE domain

  12. XM_017322316.2 → XP_017177805.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X11

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:755 → 846
    PEHE; PEHE domain

  13. XM_011238578.2 → XP_011236880.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X4

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:799 → 890
    PEHE; PEHE domain

  14. XM_011238580.2 → XP_011236882.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X7

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:789 → 880
    PEHE; PEHE domain

  15. XM_011238579.2 → XP_011236881.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X6

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:790 → 881
    PEHE; PEHE domain

  16. XM_011238576.2 → XP_011236878.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X2

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:833 → 924
    PEHE; PEHE domain

  17. XM_011238570.2 → XP_011236872.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

    See identical proteins and their annotated locations for XP_011236872.1

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:834 → 954
    PEHE; PEHE domain

  18. XM_036153357.1 → XP_036009250.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X9

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:763 → 883
    PEHE; PEHE domain

  19. XM_036153363.1 → XP_036009256.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X18

    UniProtKB/TrEMBL
    F6ULJ7
    Related
    ENSMUSP00000118603.2, ENSMUST00000129190.8
    Conserved Domains (1) summary
    pfam15275
    Location:338 → 458
    PEHE; PEHE domain

  20. XM_036153332.1 → XP_036009225.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:834 → 954
    PEHE; PEHE domain

  21. XM_036153365.1 → XP_036009258.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X19

    Conserved Domains (1) summary
    pfam15275
    Location:294 → 414
    PEHE; PEHE domain

  22. XM_006496249.3 → XP_006496312.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X15

    See identical proteins and their annotated locations for XP_006496312.1

    UniProtKB/TrEMBL
    F6ULJ7
    Conserved Domains (1) summary
    pfam15275
    Location:467 → 558
    PEHE; PEHE domain

  23. XM_030242669.2 → XP_030098529.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X13

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:720 → 811
    PEHE; PEHE domain

  24. XM_036153359.1 → XP_036009252.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X10

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:755 → 875
    PEHE; PEHE domain

  25. XM_011238575.3 → XP_011236877.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

    See identical proteins and their annotated locations for XP_011236877.1

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:834 → 954
    PEHE; PEHE domain

  26. XM_011238583.3 → XP_011236885.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X15

    See identical proteins and their annotated locations for XP_011236885.1

    UniProtKB/TrEMBL
    F6ULJ7
    Conserved Domains (1) summary
    pfam15275
    Location:467 → 558
    PEHE; PEHE domain

  27. XM_011238573.3 → XP_011236875.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

    See identical proteins and their annotated locations for XP_011236875.1

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:834 → 954
    PEHE; PEHE domain

  28. XM_011238582.4 → XP_011236884.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X15

    See identical proteins and their annotated locations for XP_011236884.1

    UniProtKB/TrEMBL
    F6ULJ7
    Conserved Domains (1) summary
    pfam15275
    Location:467 → 558
    PEHE; PEHE domain

  29. XM_011238577.4 → XP_011236879.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X3

    See identical proteins and their annotated locations for XP_011236879.1

    UniProtKB/Swiss-Prot
    B2KGC3, E9QLD1, Q3TC00, Q5DTI6, Q8BNM1, Q8C4R5
    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:799 → 919
    PEHE; PEHE domain

  30. XM_011238572.4 → XP_011236874.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

    See identical proteins and their annotated locations for XP_011236874.1

    UniProtKB/TrEMBL
    B2RUA4
    Conserved Domains (1) summary
    pfam15275
    Location:834 → 954
    PEHE; PEHE domain

  31. XM_011238581.4 → XP_011236883.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X14

    UniProtKB/TrEMBL
    E9QLE2
    Related
    ENSMUSP00000109620.2, ENSMUST00000113987.2

  32. XM_011238584.4 → XP_011236886.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X16

  33. XM_036153362.1 → XP_036009255.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X17

RNA

  1. XR_001785576.2 RNA Sequence

  2. XR_003946490.2 RNA Sequence

  3. XR_004934169.1 RNA Sequence

  4. XR_004934170.1 RNA Sequence

  5. XR_003946488.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033526.1: Suppressed sequence

    Description
    NM_001033526.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DTI6.3 GenPept UniProtKB/Swiss-Prot:Q5DTI6

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