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Hddc3 HD domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 68695, updated on 11-Apr-2024

Summary

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Official Symbol
Hddc3provided by MGI
Official Full Name
HD domain containing 3provided by MGI
Primary source
MGI:MGI:1915945
See related
Ensembl:ENSMUSG00000030532 AllianceGenome:MGI:1915945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MESH1; 1110033O09Rik
Summary
Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Orthologous to human HDDC3 (HD domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 7.4), large intestine adult (RPKM 6.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hddc3 in Genome Data Viewer
Location:
7 D2; 7 45.65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79992864..80000479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80343075..80346716)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RCC1 domain containing 1 Neighboring gene protein regulator of cytokinesis 1 Neighboring gene unc-45 myosin chaperone A Neighboring gene STARR-positive B cell enhancer ABC_E2828 Neighboring gene STARR-positive B cell enhancer ABC_E6566 Neighboring gene high mobility group box 2 pseudogene Neighboring gene mannosidase 2, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87520664-87520847 Neighboring gene feline sarcoma oncogene Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene predicted gene 44851

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions. Huang R, et al. Protein Cell, 2023 Mar 16. PMID 36929003, Free PMC Article
  2. Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory. Kim YJ, et al. Neuron, 2018 Dec 5. PMID 30344048, Free PMC Article
  3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Names
(ppGpp)ase
HD domain-containing protein 3
metazoan SpoT homolog 1
penta-phosphate guanosine-3'-pyrophosphohydrolase
NP_001405841.1
NP_001405842.1
NP_001405845.1
NP_001405846.1
NP_001405847.1
NP_001405848.1
NP_001405849.1
NP_001405850.1
NP_001405851.1
NP_081088.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418912.1 → NP_001405841.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC136740

  2. NM_001418913.1 → NP_001405842.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC136740

  3. NM_001418916.1 → NP_001405845.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC136740
    UniProtKB/TrEMBL
    A0A0U1RNF0
    Related
    ENSMUSP00000145537.2, ENSMUST00000206122.2

  4. NM_001418917.1 → NP_001405846.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC136740

  5. NM_001418918.1 → NP_001405847.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC136740
    UniProtKB/TrEMBL
    A0A0U1RQ53
    Related
    ENSMUSP00000146252.2, ENSMUST00000206074.2

  6. NM_001418919.1 → NP_001405848.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC136740

  7. NM_001418920.1 → NP_001405849.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC136740

  8. NM_001418921.1 → NP_001405850.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC136740

  9. NM_001418922.1 → NP_001405851.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC136740
    Related
    ENSMUSP00000145686.2, ENSMUST00000206480.2

  10. NM_026812.3 → NP_081088.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 1

    See identical proteins and their annotated locations for NP_081088.1

    Status: VALIDATED

    Source sequence(s)
    AC136740
    Consensus CDS
    CCDS21396.1
    UniProtKB/Swiss-Prot
    Q9D114
    Related
    ENSMUSP00000032747.6, ENSMUST00000032747.7
    Conserved Domains (2) summary
    COG0317
    Location:4 → 130
    SpoT; (p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]
    pfam13328
    Location:11 → 135
    HD_4; HD domain

RNA

  1. NR_184853.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136740

  2. NR_184854.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136740

  3. NR_184855.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136740

  4. NR_184856.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136740

  5. NR_184857.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136740

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79992864..80000479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D114.1 GenPept UniProtKB/Swiss-Prot:Q9D114

Gene LinkOut

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