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Muc3 mucin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 687030, updated on 29-Feb-2024

Summary

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Official Symbol
Muc3provided by RGD
Official Full Name
mucin 3provided by RGD
Primary source
RGD:3124
See related
AllianceGenome:RGD:3124
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Muc3a
Summary
Predicted to enable PDZ domain binding activity. Involved in response to hormone and response to vitamin A. Located in apical plasma membrane and cytoplasm. Used to study colitis. Biomarker of cholangitis; colitis; liver cirrhosis; and otitis media. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Muc3 in Genome Data Viewer
Location:
12q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (25139076..25175249)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19527251..19536924)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22535663..22584775)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene mucin-12-like Neighboring gene mucin-12-like Neighboring gene uncharacterized LOC120095911 Neighboring gene tripartite motif containing 56 Neighboring gene serpin family E member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats. Ito H, et al. J Nutr, 2009 Sep. PMID 19605529
  2. Role of N-glycosylation of the SEA module of rodent Muc3 in posttranslational processing of its carboxy-terminal domain. He Y, et al. Glycobiology, 2009 Oct. PMID 19561031
  3. Contribution of the conservative cleavage motif to posttranslational processing of the carboxyl terminal domain of rodent Muc3. Li Y, et al. Mol Cell Biochem, 2008 Jun. PMID 18401557
  4. Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3. Khatri IA, et al. Biochem J, 2004 Feb 15. PMID 14572308, Free PMC Article
  5. The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs. Khatri IA, et al. Biochim Biophys Acta, 1997 May 22. PMID 9188795

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of Muc3 gene was 3-fold higher in the colonic mucosa from high protein rats and 3.5-fold more expressed in the ileal mucosa from high protein rats than in normal protein rats.
    Title: High-protein diet differently modifies intestinal goblet cell characteristics and mucosal cytokine expression in ileum and colon.
  2. interaction of the heterodimer was independent of the N-glycans within the rodent Muc3 SEA module.
    Title: Role of N-glycosylation of the SEA module of rodent Muc3 in posttranslational processing of its carboxy-terminal domain.
  3. In rats fed the [high molecular weight konjac mannan] diet, ileal Muc2 gene expression was not affected, but that of Muc3 was lower than in those fed the control diet...
    Title: Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats.
  4. The present study demonstrates how the conservative cleavage motif LS1KGS2IV1V2 contributes to posttranslational processing through mutagenesis of each residue in the LS(1)KGS2IV1V2 motif.
    Title: Contribution of the conservative cleavage motif to posttranslational processing of the carboxyl terminal domain of rodent Muc3.
  5. Identification of a proteolytic site sequence in the C-terminal domain of Mucin3.
    Title: Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to vitamin A IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mucin 3; uncharacterized protein Muc3
Names
Mucin3
mucin 3, intestinal
mucin 3A, cell surface associated
mucin-12
mucin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    25139076..25175249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271879.1 → XP_063127949.1  uncharacterized protein Muc3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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