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Cfap68 cilia and flagella associated protein 68 [ Mus musculus (house mouse) ]

Gene ID: 68721, updated on 5-Mar-2024

Summary

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Official Symbol
Cfap68provided by MGI
Official Full Name
cilia and flagella associated protein 68provided by MGI
Primary source
MGI:MGI:1915971
See related
Ensembl:ENSMUSG00000037971 AllianceGenome:MGI:1915971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c11orf1; 1110032A03Rik; 4930500N06Rik
Summary
Predicted to be located in nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; male reproductive gland or organ; and nervous system. Orthologous to human C11orf1 (chromosome 11 open reading frame 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 65.0), genital fat pad adult (RPKM 10.5) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 27.75 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50672674..50679536, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50761374..50768236, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310030G06 gene Neighboring gene STARR-seq mESC enhancer starr_24121 Neighboring gene crystallin, alpha B Neighboring gene heat shock protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3828 Neighboring gene STARR-positive B cell enhancer ABC_E9760 Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene predicted gene, 57547

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The genomic determinants of alcohol preference in mice. Tabakoff B, et al. Mamm Genome, 2008 May. PMID 18563486, Free PMC Article
  2. Characterization of five novel human genes in the 11q13-q22 region. O'Brien KP, et al. Biochem Biophys Res Commun, 2000 Jun 24. PMID 10873569
  3. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Mulligan MK, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16618939, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cilia- and flagella-associated protein 68
Names
UPF0686 protein C11orf1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311073.2 → NP_001298002.1  cilia- and flagella-associated protein 68 isoform 2

    See identical proteins and their annotated locations for NP_001298002.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, which results in a different 5' UTR and use of an alternate start codon compared to variant 1. It encodes isoform 2, which is longer than and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK015671, AK043513, AK161835, BQ175429, BU609920
    Consensus CDS
    CCDS80996.1
    UniProtKB/Swiss-Prot
    Q9D131
    Related
    ENSMUSP00000046890.5, ENSMUST00000042576.11
    Conserved Domains (1) summary
    pfam06608
    Location:25 → 164
    DUF1143; Protein of unknown function (DUF1143)

  2. NM_001361107.1 → NP_001348036.1  cilia- and flagella-associated protein 68 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123614
    UniProtKB/TrEMBL
    H3BL73
    Related
    ENSMUSP00000135679.2, ENSMUST00000176238.2
    Conserved Domains (1) summary
    pfam06608
    Location:1 → 125
    DUF1143; Protein of unknown function (DUF1143)

  3. NM_001361108.1 → NP_001348037.1  cilia- and flagella-associated protein 68 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123614
    Consensus CDS
    CCDS90565.1
    UniProtKB/TrEMBL
    H3BJ69
    Related
    ENSMUSP00000134870.2, ENSMUST00000177546.8
    Conserved Domains (1) summary
    pfam06608
    Location:14 → 71
    DUF1143; Protein of unknown function (DUF1143)

  4. NM_023483.4 → NP_075972.2  cilia- and flagella-associated protein 68 isoform 1

    See identical proteins and their annotated locations for NP_075972.2

    Status: VALIDATED

    Source sequence(s)
    AC123614, AK043513, AK161835, BQ175429, BU609920
    Consensus CDS
    CCDS23173.1
    UniProtKB/Swiss-Prot
    Q3TM17, Q3TYP3, Q4FK47, Q8K0A6, Q9D131, Q9D589, Q9JHT0
    Related
    ENSMUSP00000041803.3, ENSMUST00000042468.9
    Conserved Domains (1) summary
    pfam06608
    Location:1 → 148
    DUF1143; Protein of unknown function (DUF1143)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50672674..50679536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244552.1 → XP_030100412.1  cilia- and flagella-associated protein 68 isoform X2

  2. XM_006510578.5 → XP_006510641.1  cilia- and flagella-associated protein 68 isoform X1

    Conserved Domains (1) summary
    pfam06608
    Location:25 → 141
    DUF1143; Protein of unknown function (DUF1143)

  3. XM_036155233.1 → XP_036011126.1  cilia- and flagella-associated protein 68 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D131.1 GenPept UniProtKB/Swiss-Prot:Q9D131

Gene LinkOut

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