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Tmem219 transmembrane protein 219 [ Mus musculus (house mouse) ]

Gene ID: 68742, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem219provided by MGI
Official Full Name
transmembrane protein 219provided by MGI
Primary source
MGI:MGI:1915992
See related
Ensembl:ENSMUSG00000060538 AllianceGenome:MGI:1915992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IGFBP-3R; 1110032O16Rik; 2900045G02Rik
Summary
Predicted to act upstream of or within apoptotic process. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human TMEM219 (transmembrane protein 219). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 65.5), duodenum adult (RPKM 54.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.25 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126485391..126527993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126886219..126928821, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene double C2, alpha Neighboring gene INO80 complex subunit E Neighboring gene STARR-positive B cell enhancer ABC_E8843 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134005673-134005856 Neighboring gene HIRA interacting protein 3 Neighboring gene TAO kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2849 Neighboring gene predicted gene, 23445 Neighboring gene STARR-positive B cell enhancer ABC_E10477 Neighboring gene potassium channel tetramerisation domain containing 13 Neighboring gene aspartate beta-hydroxylase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. D'Addio F, et al. Nat Commun, 2022 Feb 3. PMID 35115561, Free PMC Article
  2. IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses. Lee CM, et al. Nat Commun, 2016 Sep 15. PMID 27629921, Free PMC Article
  3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
insulin-like growth factor-binding protein 3 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374613.1 → NP_001361542.1  insulin-like growth factor-binding protein 3 receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122863
    Consensus CDS
    CCDS90330.1
    UniProtKB/TrEMBL
    G3X9Z3, G5E8V1
    Related
    ENSMUSP00000114040.2, ENSMUST00000119781.8
    Conserved Domains (1) summary
    pfam14940
    Location:73 → 194
    TMEM219; Transmembrane 219

  2. NM_026827.1 → NP_081103.1  insulin-like growth factor-binding protein 3 receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_081103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK004043, BP769695, BY128578
    Consensus CDS
    CCDS40133.1
    UniProtKB/Swiss-Prot
    Q9D123, Q9D6H1
    UniProtKB/TrEMBL
    G3X9Z3
    Related
    ENSMUSP00000032926.6, ENSMUST00000032926.12
    Conserved Domains (1) summary
    pfam14940
    Location:48 → 169
    TMEM219; Transmembrane 219

  3. NM_028389.1 → NP_082665.1  insulin-like growth factor-binding protein 3 receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_082665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK152526, BP769695, BY128578
    Consensus CDS
    CCDS40133.1
    UniProtKB/Swiss-Prot
    Q9D123, Q9D6H1
    UniProtKB/TrEMBL
    G3X9Z3
    Related
    ENSMUSP00000112485.2, ENSMUST00000121532.8
    Conserved Domains (1) summary
    pfam14940
    Location:48 → 169
    TMEM219; Transmembrane 219

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126485391..126527993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508155.4 → XP_006508218.1  insulin-like growth factor-binding protein 3 receptor isoform X1

    UniProtKB/TrEMBL
    G3X9Z3
    Conserved Domains (1) summary
    pfam14940
    Location:74 → 195
    TMEM219; Transmembrane 219

  2. XM_036153405.1 → XP_036009298.1  insulin-like growth factor-binding protein 3 receptor isoform X1

    UniProtKB/TrEMBL
    G3X9Z3
    Conserved Domains (1) summary
    pfam14940
    Location:74 → 195
    TMEM219; Transmembrane 219
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D123.1 GenPept UniProtKB/Swiss-Prot:Q9D123

Gene LinkOut

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