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Dtwd2 DTW domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 68857, updated on 5-Mar-2024

Summary

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Official Symbol
Dtwd2provided by MGI
Official Full Name
DTW domain containing 2provided by MGI
Primary source
MGI:MGI:1916107
See related
Ensembl:ENSMUSG00000024505 AllianceGenome:MGI:1916107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190002H09Rik; 8030470C17Rik
Summary
Predicted to enable tRNA-uridine aminocarboxypropyltransferase activity. Predicted to be involved in tRNA modification. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytoplasm and nucleus. Orthologous to human DTWD2 (DTW domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 1.3), adrenal adult (RPKM 0.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 D1; 18 27.09 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (49829212..49890255, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (49696145..49755651, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700044K03 gene Neighboring gene STARR-seq mESC enhancer starr_44563 Neighboring gene predicted gene, 32958 Neighboring gene STARR-positive B cell enhancer ABC_E4247 Neighboring gene STARR-seq mESC enhancer starr_44569 Neighboring gene predicted gene 16283 Neighboring gene STARR-positive B cell enhancer mm9_chr18:49936442-49936743 Neighboring gene STARR-positive B cell enhancer ABC_E1956 Neighboring gene RIKEN cDNA 1700065O20 gene Neighboring gene predicted gene, 57648

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables tRNA-uridine aminocarboxypropyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA-uridine aminocarboxypropyltransferase 2
Names
DTW domain-containing protein 2
NP_001164431.1
NP_081130.1
XP_006526275.1
XP_006526276.1
XP_006526277.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170960.1 → NP_001164431.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform 2

    See identical proteins and their annotated locations for NP_001164431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC112984, AK004450, AK033232, AK144689, BB868459
    Consensus CDS
    CCDS50286.1
    UniProtKB/TrEMBL
    B7ZP35
    Related
    ENSMUSP00000025383.10, ENSMUST00000025383.10
    Conserved Domains (1) summary
    cl01221
    Location:66 → 160
    DTW; DTW domain

  2. NM_026854.3 → NP_081130.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_081130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC112984, AK004450, AK033232, AK144689, BB868459
    Consensus CDS
    CCDS37815.1
    UniProtKB/Swiss-Prot
    Q9D0U1
    UniProtKB/TrEMBL
    B2RTH8
    Related
    ENSMUSP00000128219.3, ENSMUST00000163590.9
    Conserved Domains (1) summary
    pfam03942
    Location:66 → 256
    DTW; DTW domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    49829212..49890255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526214.4 → XP_006526277.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X3

    Conserved Domains (1) summary
    cl01221
    Location:362 → 414
    DTW; DTW domain

  2. XM_006526212.4 → XP_006526275.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X1

    Conserved Domains (1) summary
    pfam03942
    Location:331 → 510
    DTW; DTW domain

  3. XM_006526213.5 → XP_006526276.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X2

    Conserved Domains (1) summary
    pfam03942
    Location:254 → 433
    DTW; DTW domain

RNA

  1. XR_386011.4 RNA Sequence

  2. XR_003952540.2 RNA Sequence

  3. XR_386012.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0U1.1 GenPept UniProtKB/Swiss-Prot:Q9D0U1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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