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Rnf122 ring finger protein 122 [ Mus musculus (house mouse) ]

Gene ID: 68867, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf122provided by MGI
Official Full Name
ring finger protein 122provided by MGI
Primary source
MGI:MGI:1916117
See related
Ensembl:ENSMUSG00000039328 AllianceGenome:MGI:1916117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110063C11Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in cellular protein metabolic process; negative regulation of mitochondrial membrane potential; and positive regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in endomembrane system. Orthologous to human RNF122 (ring finger protein 122). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 11.2), CNS E11.5 (RPKM 10.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A3; 8 17.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (31601855..31623346)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (31111827..31133318)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 26 Neighboring gene STARR-positive B cell enhancer ABC_E4995 Neighboring gene predicted gene, 40484 Neighboring gene STARR-positive B cell enhancer ABC_E2861 Neighboring gene STARR-positive B cell enhancer ABC_E557 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene TELO2 interacting protein 2 Neighboring gene MAK16 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Wang W, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27506794, Free PMC Article
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF122 suppresses antiviral type I interferon production by targeting RIG-I caspase activation and recruitment domains to mediate RIG-I degradation.
    Title: RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING finger protein 122
Names
ring finger protein 122 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368373.1 → NP_001355302.1  RING finger protein 122 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109163

  2. NM_001368374.1 → NP_001355303.1  RING finger protein 122 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109163

  3. NM_001368375.1 → NP_001355304.1  RING finger protein 122 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109163
    Consensus CDS
    CCDS90381.1
    UniProtKB/Swiss-Prot
    Q80VA7, Q8BGD3, Q8BP31
    Related
    ENSMUSP00000150893.2, ENSMUST00000217278.2
    Conserved Domains (1) summary
    cd16469
    Location:91 → 137
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

  4. NM_175136.3 → NP_780345.1  RING finger protein 122 isoform 4

    See identical proteins and their annotated locations for NP_780345.1

    Status: VALIDATED

    Source sequence(s)
    AC109163
    Consensus CDS
    CCDS22220.1
    UniProtKB/TrEMBL
    A0A0R4J0G8
    Related
    ENSMUSP00000040478.8, ENSMUST00000046941.8
    Conserved Domains (1) summary
    cd16469
    Location:91 → 136
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    31601855..31623346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BP31.1 GenPept UniProtKB/Swiss-Prot:Q8BP31

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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