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Paqr6 progestin and adipoQ receptor family member VI [ Mus musculus (house mouse) ]

Gene ID: 68957, updated on 5-Mar-2024

Summary

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Official Symbol
Paqr6provided by MGI
Official Full Name
progestin and adipoQ receptor family member VIprovided by MGI
Primary source
MGI:MGI:1916207
See related
Ensembl:ENSMUSG00000041423 AllianceGenome:MGI:1916207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500001B10Rik
Summary
Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including gut; lung; pharyngo-tympanic tube; ventricular layer; and vibrissa. Orthologous to human PAQR6 (progestin and adipoQ receptor family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 11.5), ovary adult (RPKM 8.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 38.81 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88271376..88275848)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88364072..88368541)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 79 Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene bone gamma-carboxyglutamate protein 3 Neighboring gene predicted gene, 21956

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang YT, et al. J Mol Evol, 2005 Sep. PMID 16044242
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane progestin receptor delta
Names
mPR delta
membrane progesterone P4 receptor delta
membrane progesterone receptor delta
progesterone and adipoQ receptor family member 6
progestin and adipoQ receptor family member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310597.1 → NP_001297526.1  membrane progestin receptor delta isoform 2

    See identical proteins and their annotated locations for NP_001297526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in its central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK139144, BE996278
    Consensus CDS
    CCDS79941.1
    UniProtKB/TrEMBL
    D3Z1S5
    Related
    ENSMUSP00000119656.2, ENSMUST00000147948.8
    Conserved Domains (1) summary
    cl03831
    Location:71 → 161
    HlyIII; Haemolysin-III related

  2. NM_001404108.1 → NP_001391037.1  membrane progestin receptor delta isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102388
    UniProtKB/Swiss-Prot
    Q3UTT0, Q6TCG5, Q8CF56
    UniProtKB/TrEMBL
    Q0VBT6

  3. NM_001404109.1 → NP_001391038.1  membrane progestin receptor delta isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102388

  4. NM_001404110.1 → NP_001391039.1  membrane progestin receptor delta isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102388

  5. NM_198410.3 → NP_940802.1  membrane progestin receptor delta isoform 1

    See identical proteins and their annotated locations for NP_940802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI607833, AK139144
    Consensus CDS
    CCDS17471.1
    UniProtKB/Swiss-Prot
    Q3UTT0, Q6TCG5, Q8CF56
    UniProtKB/TrEMBL
    Q0VBT6
    Related
    ENSMUSP00000114166.2, ENSMUST00000147991.2
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 271
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88271376..88275848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502009.5 → XP_006502072.1  membrane progestin receptor delta isoform X2

    Conserved Domains (1) summary
    pfam03006
    Location:58 → 311
    HlyIII; Haemolysin-III related

  2. XM_006502010.3 → XP_006502073.1  membrane progestin receptor delta isoform X3

    See identical proteins and their annotated locations for XP_006502073.1

    Conserved Domains (1) summary
    pfam03006
    Location:43 → 296
    HlyIII; Haemolysin-III related
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TCG5.1 GenPept UniProtKB/Swiss-Prot:Q6TCG5

Gene LinkOut

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