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Tdrd12 tudor domain containing 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689639, updated on 5-Mar-2024

Summary

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Official Symbol
Tdrd12provided by RGD
Official Full Name
tudor domain containing 12provided by RGD
Primary source
RGD:1562792
See related
Ensembl:ENSRNOG00000012719 AllianceGenome:RGD:1562792
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562792
Summary
Predicted to enable ATP binding activity and nucleic acid binding activity. Predicted to be involved in several processes, including gamete generation; gene silencing by RNA; and piRNA metabolic process. Predicted to be part of PET complex. Orthologous to human TDRD12 (tudor domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 58.6), Kidney (RPKM 15.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (97270280..97342637, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (88133271..88205729, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91739126..91811577, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 89 Neighboring gene solute carrier family 7 member 9 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene nudix hydrolase 19 Neighboring gene regulator of G protein signaling 9 binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Yang Z, et al. Mol Cell, 2016 Jan 7. PMID 26669262, Free PMC Article
  2. Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Pandey RR, et al. Proc Natl Acad Sci U S A, 2013 Oct 8. PMID 24067652, Free PMC Article
  3. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in fertilization ISO
Inferred from Sequence Orthology
more info
  
involved_in germ-line stem cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in piRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in siRNA-mediated retrotransposon silencing by heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PET complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative ATP-dependent RNA helicase TDRD12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    97270280..97342637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590063.3 → XP_017445552.1  putative ATP-dependent RNA helicase TDRD12 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZR00, F1LTR3
    Related
    ENSRNOP00000017021.5

  2. XM_063277999.1 → XP_063134069.1  putative ATP-dependent RNA helicase TDRD12 isoform X8

  3. XM_039100861.2 → XP_038956789.1  putative ATP-dependent RNA helicase TDRD12 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZR00
    Conserved Domains (4) summary
    cd06463
    Location:1120 → 1195
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    COG0513
    Location:369 → 803
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd20435
    Location:841 → 963
    Tudor_TDRD12_rpt2; second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins
    cl02573
    Location:9 → 112
    Tudor_SF; Tudor domain superfamily

  4. XM_063277978.1 → XP_063134048.1  putative ATP-dependent RNA helicase TDRD12 isoform X1

  5. XM_017590064.3 → XP_017445553.1  putative ATP-dependent RNA helicase TDRD12 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZR00

  6. XM_039100862.2 → XP_038956790.1  putative ATP-dependent RNA helicase TDRD12 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZR00
    Conserved Domains (3) summary
    cd06463
    Location:1012 → 1087
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    COG0513
    Location:261 → 695
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd20435
    Location:733 → 855
    Tudor_TDRD12_rpt2; second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins

  7. XM_039100863.2 → XP_038956791.1  putative ATP-dependent RNA helicase TDRD12 isoform X6

    Conserved Domains (3) summary
    cd06463
    Location:869 → 944
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    COG0513
    Location:118 → 552
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd20435
    Location:590 → 712
    Tudor_TDRD12_rpt2; second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins

  8. XM_039100864.2 → XP_038956792.1  putative ATP-dependent RNA helicase TDRD12 isoform X7

    Conserved Domains (3) summary
    cd06463
    Location:545 → 620
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cl38915
    Location:20 → 134
    DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
    cd20435
    Location:266 → 388
    Tudor_TDRD12_rpt2; second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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