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Wdr74 WD repeat domain 74 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690229, updated on 11-Apr-2024

Summary

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Official Symbol
Wdr74provided by RGD
Official Full Name
WD repeat domain 74provided by RGD
Primary source
RGD:1582881
See related
Ensembl:ENSRNOG00000042878 AllianceGenome:RGD:1582881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Predicted to act upstream of or within RNA metabolic process and blastocyst formation. Predicted to be located in nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human WDR74 (WD repeat domain 74). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 112.9), Testes (RPKM 102.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215060901..215065687)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205631769..205636558)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224933906..224938659)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 5 like 1 Neighboring gene U2 spliceosomal RNA Neighboring gene testis expressed 54 Neighboring gene syntaxin 5 Neighboring gene nuclear RNA export factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Wdr74 is required for blastocyst formation in the mouse. Maserati M, et al. PLoS One, 2011. PMID 21799883, Free PMC Article
  2. Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2. Lo YH, et al. Structure, 2017 May 2. PMID 28416111, Free PMC Article
  3. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74. Hiraishi N, et al. Biochem Biophys Res Commun, 2015 Nov 20. PMID 26456651
  4. WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2. Hiraishi N, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29107693
  5. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within RNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blastocyst formation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of nuclear exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401300.1 → NP_001388229.1  WD repeat-containing protein 74

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JXL1, B0BNI2
    Related
    ENSRNOP00000070315.1, ENSRNOT00000088282.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215060901..215065687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231000.5 → XP_006231062.1  WD repeat-containing protein 74 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFE4
    Conserved Domains (2) summary
    sd00039
    Location:91 → 130
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45 → 259
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_039091404.2 → XP_038947332.1  WD repeat-containing protein 74 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:73 → 109
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:48 → 145
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001109569.1: Suppressed sequence

    Description
    NM_001109569.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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