Mitd1 MIT, microtubule interacting and transport, domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mitd1provided by MGI
Official Full Name: MIT, microtubule interacting and transport, domain containing 1provided by MGI
Primary source: MGI:MGI:1916278
See related: Ensembl:ENSMUSG00000026088 AllianceGenome:MGI:1916278
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500032H18Rik
Summary: Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein domain specific binding activity. Predicted to be involved in midbody abscission and negative regulation of protein binding activity. Predicted to act upstream of or within cell division. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be extrinsic component of membrane. Predicted to colocalize with midbody. Orthologous to human MITD1 (microtubule interacting and trafficking domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 6.1), liver E14 (RPKM 4.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 16.13 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (37913882..37929530, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (37874801..37890449, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in midbody abscission	IBA Inferred from Biological aspect of Ancestor more info
involved_in midbody abscission	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with midbody	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MIT domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356262.1 → NP_001343191.1 MIT domain-containing protein 1

Status: VALIDATED

Source sequence(s)

AC119189

Consensus CDS

CCDS35542.1

UniProtKB/Swiss-Prot

Q8VDV8, Q9DB13

Related

ENSMUSP00000123009.2, ENSMUST00000139725.8

Conserved Domains (2) summary

cd02683
Location:10 → 86

MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.

pfam16565
Location:100 → 242

MIT_C; Phospholipase D-like domain at C-terminus of MIT
NM_026913.3 → NP_081189.1 MIT domain-containing protein 1

See identical proteins and their annotated locations for NP_081189.1

Status: VALIDATED

Source sequence(s)

AC119189

Consensus CDS

CCDS35542.1

UniProtKB/Swiss-Prot

Q8VDV8, Q9DB13

Related

ENSMUSP00000027257.9, ENSMUST00000027257.10

Conserved Domains (2) summary

cd02683
Location:10 → 86

MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.

pfam16565
Location:100 → 242

MIT_C; Phospholipase D-like domain at C-terminus of MIT

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

37913882..37929530 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322349.2 → XP_017177838.1 MIT domain-containing protein 1 isoform X2

Conserved Domains (1) summary

pfam16565
Location:68 → 181

MIT_C; Phospholipase D-like domain at C-terminus of MIT
XM_036153403.1 → XP_036009296.1 MIT domain-containing protein 1 isoform X1

Conserved Domains (2) summary

cd02683
Location:10 → 86

MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.

cl02780
Location:100 → 198

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.