Pnlip pancreatic lipase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pnlipprovided by MGI
Official Full Name: pancreatic lipaseprovided by MGI
Primary source: MGI:MGI:97722
See related: Ensembl:ENSMUSG00000046008 AllianceGenome:MGI:97722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PL; PTL; 1810007A24Rik
Summary: Enables triglyceride lipase activity. Acts upstream of or within intestinal cholesterol absorption. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in pons and pons mantle layer. Orthologous to human PNLIP (pancreatic lipase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in small intestine adult (RPKM 823.6), spleen adult (RPKM 764.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 54.46 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (58658797..58670231)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (58670365..58681799)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis.
Title: Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis.
Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation.
Title: Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation.
Undercarboxylated osteocalcin downregulates pancreatic lipase expression in an ATF4-dependent manner in pancreatic acinar cells.
Title: Undercarboxylated osteocalcin downregulates pancreatic lipase expression in an ATF4-dependent manner in pancreatic acinar cells.
the ability to degrade unfolded protein decreases in the aging pancreas, and this leads to reduction of pancreatic lipase activity and a decrease in lipid absorption
Title: Decreased lipid absorption due to reduced pancreatic lipase activity in aging male mice.
PTL and CEL serve complementary functions, working together to mediate the absorption of a major portion of dietary fat and fat-soluble vitamin esters
Title: Carboxyl ester lipase deficiency exacerbates dietary lipid absorption abnormalities and resistance to diet-induced obesity in pancreatic triglyceride lipase knockout mice.
pancreatic triglyceride lipase has a critical role in dietary cholesterol absorption and a minimal role in dietary fat absorption in mice
Title: Pancreatic triglyceride lipase deficiency minimally affects dietary fat absorption but dramatically decreases dietary cholesterol absorption in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables triglyceride lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triglyceride lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triglyceride lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intestinal cholesterol absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride lipase activity	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pancreatic triacylglycerol lipase

Names: pancreatic triglyceride lipase

NP_081201.2

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026925.4 → NP_081201.2 pancreatic triacylglycerol lipase precursor

See identical proteins and their annotated locations for NP_081201.2

Status: VALIDATED

Source sequence(s)

AV049089, BC061061

Consensus CDS

CCDS29930.1

UniProtKB/Swiss-Prot

Q6P8U6

Related

ENSMUSP00000056377.8, ENSMUST00000057270.9

Conserved Domains (3) summary

cd00707
Location:51 → 348

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01759
Location:355 → 465

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

pfam00151
Location:18 → 352

Lipase; Lipase