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Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI [ Rattus norvegicus (Norway rat) ]

Gene ID: 690848, updated on 5-Mar-2024

Summary

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Official Symbol
Uqcr11provided by RGD
Official Full Name
ubiquinol-cytochrome c reductase, complex III subunit XIprovided by RGD
Primary source
RGD:1590985
See related
AllianceGenome:RGD:1590985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Uqcr
Summary
Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex III. Orthologous to human UQCR11 (ubiquinol-cytochrome c reductase, complex III subunit XI). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 2309.2), Muscle (RPKM 1584.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9955717..9960432)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9305042..9309753)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12171146..12175838)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transcription factor 3 Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene mex-3 RNA binding family member D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria. Xu F, et al. Biochem J, 2008 Nov 15. PMID 18729827
  2. Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria. Schilling B, et al. Biochim Biophys Acta, 2006 Feb. PMID 16120479
  3. Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2). Guo R, et al. Cell, 2017 Sep 7. PMID 28844695
  4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquinol-cytochrome c reductase, complex III subunit XI
Names
cytochrome b-c1 complex subunit 10
ubiquinol-cytochrome c reductase, 6.4kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126097.2 → NP_001119569.1  ubiquinol-cytochrome c reductase, complex III subunit XI

    See identical proteins and their annotated locations for NP_001119569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC157815, CB783645, FM080527
    UniProtKB/TrEMBL
    A9UMV7
    Conserved Domains (1) summary
    pfam08997
    Location:2 → 52
    UCR_6-4kD; Ubiquinol-cytochrome C reductase complex, 6.4kD protein

  2. NM_001287109.1 → NP_001274038.1  ubiquinol-cytochrome c reductase, complex III subunit XI

    See identical proteins and their annotated locations for NP_001274038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CB783645, FM080527
    UniProtKB/TrEMBL
    A9UMV7
    Conserved Domains (1) summary
    pfam08997
    Location:2 → 52
    UCR_6-4kD; Ubiquinol-cytochrome C reductase complex, 6.4kD protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9955717..9960432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241008.4 → XP_006241070.1  ubiquinol-cytochrome c reductase, complex III subunit XI isoform X1

    See identical proteins and their annotated locations for XP_006241070.1

    UniProtKB/TrEMBL
    A9UMV7
    Conserved Domains (1) summary
    pfam08997
    Location:2 → 52
    UCR_6-4kD; Ubiquinol-cytochrome C reductase complex, 6.4kD protein
Nucleotide Protein Strain
Heading Accession and Version

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