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Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 691318, updated on 13-Apr-2024

Summary

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Official Symbol
Ppp2r5cprovided by RGD
Official Full Name
protein phosphatase 2, regulatory subunit B', gammaprovided by RGD
Primary source
RGD:1585097
See related
Ensembl:ENSRNOG00000004973 AllianceGenome:RGD:1585097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable peptidase activity and protein phosphatase activator activity. Predicted to be involved in negative regulation of cell population proliferation; protein dephosphorylation; and signal transduction by p53 class mediator. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process and protein processing. Predicted to be located in Golgi apparatus; chromosome, centromeric region; and nucleoplasm. Predicted to be integral component of membrane. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Orthologous to human PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 299.9), Heart (RPKM 229.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (135282947..135419591)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (129461689..129598344)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (134804128..134941912)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546759 Neighboring gene ribosomal protein S21, pseudogene 4 Neighboring gene uncharacterized LOC102547242 Neighboring gene uncharacterized LOC120103624 Neighboring gene dynein cytoplasmic 1 heavy chain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes. Glaser ND, et al. Am J Physiol Heart Circ Physiol, 2006 Sep. PMID 16603688, Free PMC Article
  2. Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes. Bhasin N, et al. Am J Physiol Heart Circ Physiol, 2007 Jul. PMID 17416611
  3. Structure of the protein phosphatase 2A holoenzyme. Xu Y, et al. Cell, 2006 Dec 15. PMID 17174897
  4. miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2. Terentyev D, et al. Circ Res, 2009 Feb 27. PMID 19131648, Free PMC Article
  5. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Tang Z, et al. Dev Cell, 2006 May. PMID 16580887

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.
    Title: miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.
  2. These new data implicate ankyrin-B as a critical targeting component for PP2A in heart and identify a new class of signaling proteins targeted by ankyrin polypeptides.
    Title: Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes.
  3. In an established model of sustained JNK activation, a 70% decrease in expression of the targeting subunit of PP2A, B56alpha, was observed in either neonatal or adult cardiomyocytes.
    Title: JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191112.2 → NP_001178041.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AAX1, D4A1A5
    Related
    ENSRNOP00000007595.5, ENSRNOT00000007595.8
    Conserved Domains (1) summary
    pfam01603
    Location:34 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. NM_001415125.1 → NP_001402054.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001415126.1 → NP_001402055.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5ZRT0
    Related
    ENSRNOP00000080856.1, ENSRNOT00000104738.1

  4. NM_001415127.1 → NP_001402056.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AKJ3
    Related
    ENSRNOP00000089250.1, ENSRNOT00000095073.1

  5. NM_001415128.1 → NP_001402057.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6A0C3
    Related
    ENSRNOP00000085964.1, ENSRNOT00000113176.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    135282947..135419591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262522.1 → XP_063118592.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

  2. XM_039112971.2 → XP_038968899.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZD1, A0A8I5ZRC2
    Related
    ENSRNOP00000079611.1
    Conserved Domains (1) summary
    pfam01603
    Location:88 → 491
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. XM_008764962.4 → XP_008763184.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

    UniProtKB/TrEMBL
    A0A0G2JZD1
    Conserved Domains (2) summary
    PLN00122
    Location:396 → 496
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:88 → 491
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  4. XM_063262527.1 → XP_063118597.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

  5. XM_039112973.2 → XP_038968901.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7

    UniProtKB/TrEMBL
    A0A8I6AAX1
    Conserved Domains (1) summary
    pfam01603
    Location:34 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  6. XM_063262524.1 → XP_063118594.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

  7. XM_039112974.2 → XP_038968902.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X8

    UniProtKB/TrEMBL
    A0A0G2JZD1
    Conserved Domains (1) summary
    pfam01603
    Location:34 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  8. XM_063262525.1 → XP_063118595.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6

  9. XM_063262523.1 → XP_063118593.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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