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Snx4 sorting nexin 4 [ Mus musculus (house mouse) ]

Gene ID: 69150, updated on 21-Apr-2024

Summary

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Official Symbol
Snx4provided by MGI
Official Full Name
sorting nexin 4provided by MGI
Primary source
MGI:MGI:1916400
See related
Ensembl:ENSMUSG00000022808 AllianceGenome:MGI:1916400
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810036H14Rik
Summary
Predicted to enable phosphatidylinositol binding activity and signaling receptor binding activity. Predicted to be involved in endocytic recycling; positive regulation of histamine secretion by mast cell; and protein transport. Predicted to be located in early endosome membrane and plasma membrane. Predicted to be part of SNARE complex and cytoplasmic dynein complex. Orthologous to human SNX4 (sorting nexin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 23.3), limb E14.5 (RPKM 14.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 23.77 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33071826..33119932)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33251456..33299562)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:33185069-33185370 Neighboring gene oxysterol binding protein-like 11 Neighboring gene STARR-seq mESC enhancer starr_40685 Neighboring gene predicted gene, 52274 Neighboring gene STARR-positive B cell enhancer ABC_E8629 Neighboring gene STARR-seq mESC enhancer starr_40689 Neighboring gene STARR-seq mESC enhancer starr_40691 Neighboring gene STARR-seq mESC enhancer starr_40692 Neighboring gene RIKEN cDNA 1700007L15 gene Neighboring gene STARR-seq mESC enhancer starr_40693 Neighboring gene zinc finger protein 148

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The endosomal protein sorting nexin 4 is a synaptic protein. Vazquez-Sanchez S, et al. Sci Rep, 2020 Oct 26. PMID 33106523, Free PMC Article
  2. Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1. Kim NY, et al. Alzheimers Res Ther, 2017 Jan 21. PMID 28109317, Free PMC Article
  3. Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. Leprince C, et al. J Cell Sci, 2003 May 15. PMID 12668730
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The endosomal protein sorting nexin 4 is a synaptic protein.
    Title: The endosomal protein sorting nexin 4 is a synaptic protein.
  2. Results indicate that SNX4-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.
    Title: Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1.
  3. Sorting nexin 4 and amphiphysin 2 have roles in endocytosis and intracellular trafficking
    Title: Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables leptin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic endosome IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in presynaptic endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080557.2 → NP_542124.1  sorting nexin-4

    See identical proteins and their annotated locations for NP_542124.1

    Status: PROVISIONAL

    Source sequence(s)
    AC145198
    Consensus CDS
    CCDS28129.1
    UniProtKB/Swiss-Prot
    Q91YJ2
    UniProtKB/TrEMBL
    Q80X54
    Related
    ENSMUSP00000023502.5, ENSMUST00000023502.6
    Conserved Domains (3) summary
    cd06864
    Location:58 → 184
    PX_SNX4; The phosphoinositide binding Phox Homology domain of Sorting Nexin 4
    cd07622
    Location:205 → 448
    BAR_SNX4; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 4
    pfam11221
    Location:324 → 398
    Med21; Subunit 21 of Mediator complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    33071826..33119932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YJ2.1 GenPept UniProtKB/Swiss-Prot:Q91YJ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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