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Pacs2 phosphofurin acidic cluster sorting protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691631, updated on 13-Apr-2024

Summary

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Official Symbol
Pacs2provided by RGD
Official Full Name
phosphofurin acidic cluster sorting protein 2provided by RGD
Primary source
RGD:1597262
See related
Ensembl:ENSRNOG00000014744 AllianceGenome:RGD:1597262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in endoplasmic reticulum calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering; and protein localization to plasma membrane. Predicted to act upstream of or within protein localization to phagophore assembly site. Predicted to be located in endoplasmic reticulum and mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 66. Orthologous to human PACS2 (phosphofurin acidic cluster sorting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 163.7), Thymus (RPKM 114.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pacs2 in Genome Data Viewer
Location:
6q32
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137918040..137977767)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (132096992..132156702)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137824136..137889144)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 14 Neighboring gene BRF1, RNA polymerase III transcription initiation factor subunit Neighboring gene BTB domain containing 6 Neighboring gene uncharacterized LOC134479482 Neighboring gene uncharacterized LOC134479483 Neighboring gene U4 spliceosomal RNA Neighboring gene testis expressed 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure. Zhou F, et al. Eur Rev Med Pharmacol Sci, 2019 Jun. PMID 31210325
  2. miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2. Wang J, et al. RNA Biol, 2014. PMID 24646523, Free PMC Article
  3. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. Simmen T, et al. EMBO J, 2005 Feb 23. PMID 15692567, Free PMC Article
  4. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. Köttgen M, et al. EMBO J, 2005 Feb 23. PMID 15692563, Free PMC Article
  5. Autophagosomes form at ER-mitochondria contact sites. Hamasaki M, et al. Nature, 2013 Mar 21. PMID 23455425

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure.
    Title: MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure.
  2. miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2.
    Title: miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion-endoplasmic reticulum membrane tethering ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to phagophore assembly site ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphofurin acidic cluster sorting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427329.1 → NP_001414258.1  phosphofurin acidic cluster sorting protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    137918040..137977767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240668.5 → XP_006240730.1  phosphofurin acidic cluster sorting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006240730.1

    UniProtKB/TrEMBL
    A0A8I6A754, D3ZJG4
    Related
    ENSRNOP00000053720.4
    Conserved Domains (1) summary
    pfam10254
    Location:473 → 898
    Pacs-1; PACS-1 cytosolic sorting protein

  2. XM_063262529.1 → XP_063118599.1  phosphofurin acidic cluster sorting protein 2 isoform X8

  3. XM_017594524.3 → XP_017450013.1  phosphofurin acidic cluster sorting protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A754

  4. XM_039113422.2 → XP_038969350.1  phosphofurin acidic cluster sorting protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A754
    Conserved Domains (1) summary
    pfam10254
    Location:448 → 873
    Pacs-1; PACS-1 cytosolic sorting protein

  5. XM_017594525.3 → XP_017450014.1  phosphofurin acidic cluster sorting protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A754

  6. XM_063262528.1 → XP_063118598.1  phosphofurin acidic cluster sorting protein 2 isoform X6

  7. XM_017594526.2 → XP_017450015.1  phosphofurin acidic cluster sorting protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A831

  8. XM_039113423.2 → XP_038969351.1  phosphofurin acidic cluster sorting protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A831
    Conserved Domains (1) summary
    pfam10254
    Location:406 → 831
    Pacs-1; PACS-1 cytosolic sorting protein

RNA

  1. XR_005506363.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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