Myh2 myosin heavy chain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh2provided by RGD
Official Full Name: myosin heavy chain 2provided by RGD
Primary source: RGD:620354
See related: Ensembl:ENSRNOG00000065740 AllianceGenome:RGD:620354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Myh1; Myh2a; MyHC-2A; MyHC-IIA
Summary: Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Predicted to be involved in muscle contraction. Predicted to act upstream of or within actin-mediated cell contraction; plasma membrane repair; and response to activity. Predicted to be located in several cellular components, including A band; Golgi apparatus; and actomyosin contractile ring. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in inclusion body myositis and proximal myopathy and ophthalmoplegia. Orthologous to human MYH2 (myosin heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 24451.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (52355739..52382235)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (51856738..51883236)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (53711895..53738164)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plantar Mechanical Stimulation Maintains Slow Myosin Expression in Disused Rat Soleus Muscle via NO-Dependent Signaling.
Title: Plantar Mechanical Stimulation Maintains Slow Myosin Expression in Disused Rat Soleus Muscle via NO-Dependent Signaling.
Data suggest that the myosin-II mediated drebrin A-actin exodus might be an initial event in chemical long-term potentiation (LTP) induction, triggering actin polymerization and spine enlargement.
Title: Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines.
Initial actin coating of fused vesicles is dependent on activation of Rho and formin-dependent actin nucleation. Actin coat contraction is facilitated by myosin II.
Title: Actin coating and compression of fused secretory vesicles are essential for surfactant secretion--a role for Rho, formins and myosin II.
After physical training, the proportion of type IIb MyHC was lower in old animals than in adult animals. Endurance training produced a fast-to-slow shift within type II MyHC isoforms in both adult and old animals.
Title: Effects of ageing and endurance exercise training on alpha-actinin isoforms in rat plantaris muscle.
myosin-IIB protein and mRNA are expressed at high levels in diabetic brains
Title: Overexpression of myosin-IIB in the brain of a rat model of streptozotocin-induced diabetes.
In the cross-innervated thyroarytenoid, the sternohyoid nerve failed to induce 2A MyHC expression and failed to suppress extraocular MyHC expression in 2b/eo fibers.
Title: Immunohistochemical analysis of the effects of cross-innervation of murine thyroarytenoid and sternohyoid muscles.
Exercise training showed a myosin heavy chain sshift from type IIb to IIa skeletal muscle.
Title: Different adaptations of alpha-actinin isoforms to exercise training in rat skeletal muscles.
our results suggest that non-muscle myosin II is involved in the retrograde trafficking of NR1 subunits of the NMDA recptor
Title: A non-muscle myosin II motor links NR1 to retrograde trafficking and proteasomal degradation in PC12 cells.
MyHC2a levels were not different on immunoblots of the soleus of streptozocin-treated and control rats. However, the SERCA2a level was about 50% lower (P = 0.0002) in the soleus of streptozocin-treated rats compared to that of the controls. This
Title: The slow sarco/endoplasmic reticulum Ca2+ -ATPase declines independently of slow myosin in soleus muscle of diabetic rats.
Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.
Title: Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin-mediated cell contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in myosin filament assembly	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within plasma membrane repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in A band	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in actomyosin contractile ring	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-2

Names: 2A myosin heavy chain; myosin heavy chain IIa; myosin heavy chain type IIx; myosin, heavy chain 2, skeletal muscle, adult; myosin, heavy polypeptide 2, skeletal muscle, adult

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135157.1 → NP_001128629.1 myosin-2

See identical proteins and their annotated locations for NP_001128629.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K0F5, A6HFI0, G3V6E1

Related

ENSRNOP00000004236.7, ENSRNOT00000004236.7

Conserved Domains (3) summary

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 73

Myosin_N; Myosin N-terminal SH3-like domain

cl22853
Location:100 → 773

Motor_domain; Myosin and Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

52355739..52382235

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086900.2 → XP_038942828.1 myosin-2 isoform X1

UniProtKB/TrEMBL

A0A0G2K0F5, A6HFI0, G3V6E1

Conserved Domains (3) summary

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 73

Myosin_N; Myosin N-terminal SH3-like domain

cl22853
Location:100 → 773

Motor_domain; Myosin and Kinesin motor domain