Lpar6 lysophosphatidic acid receptor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lpar6provided by RGD
Official Full Name: lysophosphatidic acid receptor 6provided by RGD
Primary source: RGD:1595950
See related: Ensembl:ENSRNOG00000015577 AllianceGenome:RGD:1595950
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2ry5
Summary: Predicted to enable lysophosphatidic acid receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hypotrichosis. Orthologous to human LPAR6 (lysophosphatidic acid receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15q11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (54826110..54827919)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (48416548..48418357)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (55126953..55128762)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the up-regulation of serum ATX in hepatic encephalopathy may activate the LPA-LPA6-G12/13-Rho pathway in brain capillary endothelial cells.
Title: Lysophosphatidic acid receptor, LPA(6), regulates endothelial blood-brain barrier function: Implication for hepatic encephalopathy.
P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion.
Title: P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lysophosphatidic acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst hatching	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: lysophosphatidic acid receptor 6

Names: LPA receptor 6; LPA-6; P2Y purinoceptor 5; P2Y5; oleoyl-L-alpha-lysophosphatidic acid receptor; purinergic receptor 5; purinergic receptor P2Y, G-protein coupled, 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045843.1 → NP_001039308.1 lysophosphatidic acid receptor 6

See identical proteins and their annotated locations for NP_001039308.1

Status: PROVISIONAL

Source sequence(s)

BC098703

UniProtKB/Swiss-Prot

Q4G072

UniProtKB/TrEMBL

A6HTQ4

Related

ENSRNOP00000021430.2, ENSRNOT00000021430.4

Conserved Domains (2) summary

pfam00001
Location:35 → 291

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 142

7tm_4; Olfactory receptor