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Snx5 sorting nexin 5 [ Mus musculus (house mouse) ]

Gene ID: 69178, updated on 21-Apr-2024

Summary

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Official Symbol
Snx5provided by MGI
Official Full Name
sorting nexin 5provided by MGI
Primary source
MGI:MGI:1916428
See related
Ensembl:ENSMUSG00000027423 AllianceGenome:MGI:1916428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2Ertd52e; 0910001N05Rik; 1810032P22Rik
Summary
Predicted to enable D1 dopamine receptor binding activity; dynactin binding activity; and phosphatidylinositol phosphate binding activity. Predicted to be involved in several processes, including positive regulation of renal sodium excretion; regulation of signal transduction; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within endocytosis and protein transport. Predicted to be located in several cellular components, including brush border; macropinocytic cup; and tubular endosome. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and extrinsic component of endosome membrane. Predicted to be part of retromer complex. Predicted to be active in endosome. Predicted to colocalize with early endosome membrane. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and sensory organ. Orthologous to human SNX5 (sorting nexin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 42.1), liver E14 (RPKM 37.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G1; 2 70.98 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144092043..144112713, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144250123..144270902, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene barrier to autointegration factor 2, opposite strand Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr2:143993097-143993397 Neighboring gene STARR-positive B cell enhancer mm9_chr2:143995491-143995792 Neighboring gene STARR-positive B cell enhancer ABC_E1602 Neighboring gene predicted gene 5535 Neighboring gene STARR-seq mESC enhancer starr_05906 Neighboring gene STARR-positive B cell enhancer ABC_E11163 Neighboring gene STARR-positive B cell enhancer ABC_E5993 Neighboring gene STARR-positive B cell enhancer ABC_E9535 Neighboring gene STARR-positive B cell enhancer ABC_E1256 Neighboring gene STARR-positive B cell enhancer ABC_E7865 Neighboring gene STARR-seq mESC enhancer starr_05907 Neighboring gene STARR-positive B cell enhancer ABC_E4507 Neighboring gene STARR-positive B cell enhancer ABC_E5994 Neighboring gene STARR-positive B cell enhancer ABC_E5995 Neighboring gene STARR-seq mESC enhancer starr_05908 Neighboring gene predicted gene, 26165 Neighboring gene small nucleolar RNA, C/D box 17 Neighboring gene STARR-positive B cell enhancer ABC_E9536 Neighboring gene mitochondrial genome maintenance exonuclease 1 Neighboring gene ovo like zinc finger 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sorting nexin-5 is not required for normal spermatogenesis and male fertilization in mice. Zhou Q, et al. Mol Reprod Dev, 2020 Dec. PMID 33118244
  2. Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression. Jitsukawa S, et al. J Pathol, 2017 Nov. PMID 28771744
  3. Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages. Lim JP, et al. J Cell Sci, 2015 Dec 1. PMID 26459636
  4. Sorting nexin 5 mediates virus-induced autophagy and immunity. Dong X, et al. Nature, 2021 Jan. PMID 33328639, Free PMC Article
  5. Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction. Elwell CA, et al. Elife, 2017 Mar 2. PMID 28252385, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sorting nexin-5 is not required for normal spermatogenesis and male fertilization in mice.
    Title: Sorting nexin-5 is not required for normal spermatogenesis and male fertilization in mice.
  2. Sorting nexin 5 mediates virus-induced autophagy and immunity.
    Title: Sorting nexin 5 mediates virus-induced autophagy and immunity.
  3. Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5.
    Title: Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.
  4. thyroid cancer model using carcinogen and an anti-thyroidal agent revealed that Snx5(-/-) mice developed metastasizing thyroid tumors with activation of MAP kinase and AKT pathways
    Title: Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression.
  5. findings reveal the important contribution of dorsal ruffing to receptor-activated macropinocytosis in primary macrophages and show that SNX5 selectively regulates macropinosomes derived from the dorsal ruffles.
    Title: Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages.
  6. Histological analysis revealed that Snx5(-/-) mice exhibited thickened alveolar walls associated with undifferentiated alveolar epithelial type I cells. In contrast, type II cells were intact, exhibiting normal surfactant synthesis and secretion.
    Title: Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice.
  7. Data indicate high expression of sorting nexin 5 (Snx5) in chemically induced papillary thyroid carcinoma.
    Title: Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.
  8. SNX5 requires the generation of phosphoinositides for recruitment to the plasma membrane and, moreover, influences the level of macropinocytic activity
    Title: A role for SNX5 in the regulation of macropinocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables dynactin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynactin binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermal growth factor catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in pinocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pinocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in macropinocytic cup ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
  
located_in tubular endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199188.2 → NP_001186117.1  sorting nexin-5

    See identical proteins and their annotated locations for NP_001186117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL808123, AL824710
    Consensus CDS
    CCDS16815.1
    UniProtKB/Swiss-Prot
    Q543N9, Q9D8U8
    UniProtKB/TrEMBL
    Q3TJN6, Q8C5E7
    Related
    ENSMUSP00000105657.4, ENSMUST00000110030.10
    Conserved Domains (2) summary
    cd07663
    Location:185 → 402
    BAR_SNX5; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5
    cl02563
    Location:29 → 169
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. NM_024225.6 → NP_077187.1  sorting nexin-5

    See identical proteins and their annotated locations for NP_077187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL808123, AL824710
    Consensus CDS
    CCDS16815.1
    UniProtKB/Swiss-Prot
    Q543N9, Q9D8U8
    UniProtKB/TrEMBL
    Q3TJN6, Q8C5E7
    Related
    ENSMUSP00000028909.5, ENSMUST00000028909.5
    Conserved Domains (2) summary
    cd07663
    Location:185 → 402
    BAR_SNX5; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5
    cl02563
    Location:29 → 169
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    144092043..144112713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8U8.1 GenPept UniProtKB/Swiss-Prot:Q9D8U8

Gene LinkOut

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