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Snx5 sorting nexin 5 [ Mus musculus (house mouse) ]

Gene ID: 69178, updated on 23-Jun-2021

Summary

Official Symbol
Snx5provided by MGI
Official Full Name
sorting nexin 5provided by MGI
Primary source
MGI:MGI:1916428
See related
Ensembl:ENSMUSG00000027423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AU019504; D2Ertd52; D2Ertd52e; 0910001N05Rik; 1810032P22Rik
Expression
Ubiquitous expression in placenta adult (RPKM 42.1), liver E14 (RPKM 37.2) and 28 other tissues See more
Orthologs
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Genomic context

See Snx5 in Genome Data Viewer
Location:
2 G1; 2 70.98 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144092043..144112822, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144250123..144270902, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (144075862..144096267, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene barrier to autointegration factor 2, opposite strand Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene 5535 Neighboring gene predicted gene, 26165 Neighboring gene small nucleolar RNA, C/D box 17 Neighboring gene mitochondrial genome maintenance exonuclease 1 Neighboring gene ovo like zinc finger 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables dynactin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynactin binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermal growth factor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in pinocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pinocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in macropinocytic cup ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
 
located_in tubular endosome ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199188.1NP_001186117.1  sorting nexin-5

    See identical proteins and their annotated locations for NP_001186117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK031873, AL808123, BM120064
    Consensus CDS
    CCDS16815.1
    UniProtKB/Swiss-Prot
    Q9D8U8
    Related
    ENSMUSP00000105657.4, ENSMUST00000110030.10
    Conserved Domains (2) summary
    cd07663
    Location:185402
    BAR_SNX5; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5
    cl02563
    Location:29169
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. NM_024225.5NP_077187.1  sorting nexin-5

    See identical proteins and their annotated locations for NP_077187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK029463, AK169545, BM120064
    Consensus CDS
    CCDS16815.1
    UniProtKB/Swiss-Prot
    Q9D8U8
    Related
    ENSMUSP00000028909.5, ENSMUST00000028909.5
    Conserved Domains (2) summary
    cd07663
    Location:185402
    BAR_SNX5; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5
    cl02563
    Location:29169
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    144092043..144112822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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